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Meta-Analysis
. 2024 Jul 1;103(7):611-616.
doi: 10.1097/PHM.0000000000002419. Epub 2024 Jan 6.

Association of Age and Sex at Onset With Glenohumeral Osteoarthritis: A Systematic Review and Meta-analysis

Ravi Prakash  1 , James E Gardner, Ursa Bezan Petric, Rashmi Pathak, Folefac Atem, Nitin B Jain
Affiliations
Meta-Analysis

Association of Age and Sex at Onset With Glenohumeral Osteoarthritis: A Systematic Review and Meta-analysis

Ravi Prakash et al. Am J Phys Med Rehabil. .

Abstract

Objective: The aim of the present systematic review is to synthesize existing evidence (qualitative and quantitative) regarding age- and sex-specific differences with glenohumeral osteoarthritis.

Design: The electronic databases PubMed, MEDLINE, and Web of Science were searched up to March 15, 2023. Articles reporting on the association of risk factors (age and sex) with glenohumeral osteoarthritis were considered. We used Newcastle-Ottawa Scale to assess study quality. Meta-analysis was conducted to quantitatively summarize the association of age and sex with glenohumeral osteoarthritis.

Results: A total of 24 articles were retrieved for full-text review. Of 24 articles, 8 reporting age-specific and 5 articles reporting sex-specific associations with glenohumeral osteoarthritis were included. The odds ratio for the age (odds ratio = 3.18; 95% confidence interval = 1.10-15.92) and female sex (odds ratio = 1.78; 95% confidence interval = 0.95-3.42) were increased and observed statistically significant.

Conclusions: The present systematic review and meta-analysis suggests the role of increasing age as one of the significant contributors to glenohumeral osteoarthritis. However, association of female sex with glenohumeral osteoarthritis is least convincing. Future studies are required to understand the molecular mechanisms behind the contributory role of increasing age and female sex in the establishment of glenohumeral osteoarthritis.

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Conflict of interest statement

Financial disclosure statements have been obtained, and no conflicts of interest have been reported by the authors or by any individuals in control of the content of this article.

Figures

Fig. 1:
Fig. 1:
PRISMA flow diagram for the systematic review
Fig. 2:
Fig. 2:
Forest plot showing association between age and glenohumeral osteoarthritis. Figure showing effect estimates (odds ratios), 95% confidence intervals and the summary measure of contributing studies evaluating the association between age and glenohumeral osteoarthritis.
Fig. 3:
Fig. 3:
Forest plot showing association between sex and glenohumeral osteoarthritis. Figure showing effect estimates (odds ratios), 95% confidence intervals and the summary measure of contributing studies evaluating the association between sex and glenohumeral osteoarthritis.
See this image and copyright information in PMC

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