Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2024 Jan 10;32(1):3-4.
doi: 10.1016/j.chom.2023.12.011.

Better than being aPARt: S. aureus itches to get close to sensory neurons

Zhe Chen  1 , Sha Huang  2 , Yanlin Su  3
Affiliations
Free article
Comment

Better than being aPARt: S. aureus itches to get close to sensory neurons

Zhe Chen et al. Cell Host Microbe. .
Free article

Abstract

In a recent issue of Cell, Deng et al. show that S. aureus serine protease V8 triggers itch, independent of inflammation, by activating sensory neurons through PAR1. This study presents mechanistic insights into pruritogenic bacteria and their interactions with sensory neurons while providing a possible approach for treating itch-related diseases.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis.
    Deng L, Costa F, Blake KJ, Choi S, Chandrabalan A, Yousuf MS, Shiers S, Dubreuil D, Vega-Mendoza D, Rolland C, Deraison C, Voisin T, Bagood MD, Wesemann L, Frey AM, Palumbo JS, Wainger BJ, Gallo RL, Leyva-Castillo JM, Vergnolle N, Price TJ, Ramachandran R, Horswill AR, Chiu IM. Deng L, et al. Cell. 2023 Nov 22;186(24):5375-5393.e25. doi: 10.1016/j.cell.2023.10.019. Cell. 2023. PMID: 37995657 Free PMC article.

Similar articles

See all similar articles

References

LinkOut - more resources