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. 2024 May;34(5):341-342.
doi: 10.1038/s41422-023-00924-x.

A perfect storm: sleep loss causes systemic inflammation and death

Affiliations

A perfect storm: sleep loss causes systemic inflammation and death

Andrew D Nguyen et al. Cell Res. 2024 May.
No abstract available

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Figures

Fig. 1
Fig. 1. Potential therapeutic interventions for sleep loss-induced immune dysfunction.
TSD triggers a cascade of immune responses that lead to death. During prolonged sleep loss, PGD2 accumulates in the brain and gets shuttled out of the brain by ABCC4 transporters, and can then bind to DP1 receptor on the ventral surface of the brain, leading to accumulation of proinflammatory cytokines, neutrophilia, and multi-organ failures. Targeting this PGD2/DP1 axis through inhibiting PGD2 synthesis, blocking ABCC4 efflux activity, or treating with a DP1 antagonist may alleviate the consequences of TSD. MODS, multiple organ dysfunction syndrome. Created with BioRender.com.

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