Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024;20(4):373-378.
doi: 10.2174/0115733971283009231225144322.

Effects of Glucosamine in the Temporomandibular Joint Osteoarthritis: A Review

Sasidharan Sivakumar  1   2 , Gowardhan Sivakumar  3 , Ashok K Sundramoorthy  4
Affiliations
Review

Effects of Glucosamine in the Temporomandibular Joint Osteoarthritis: A Review

Sasidharan Sivakumar et al. Curr Rheumatol Rev. 2024.

Abstract

Osteoarthritis in the temporomandibular joint (TMJ) is a chronic disease characterized by irreversible damage to articular surfaces, including inflammation, loss of articular cartilage, and subchondral bone alterations, which would be radiographically evident only in later stages. Symptomatic slow-acting so-called nutraceutical drugs have been proposed as a treatment for osteoarthritis in comparison to non-steroidal anti-inflammatory drugs (NSAID) because of their appreciable safety profile even in long-term intake. Glucosamine, being one among them, proved highly efficient in knee osteoarthritis. However, its application in TMJ osteoarthritis dates back only to 2001 and is still inconclusive in its efficiency even with systematic reviews, in restoring the structural and functional aspects of damaged TMJ. Glucosamine, being a natural compound and also a contributor to building the matrix of articular cartilage, can be utilized effectively for TMJ osteoarthritis as an adjunct along with other conventional treatment modalities available till now, which also have moderate prognosis in most of the clinical scenarios. This review summarizes data relating to the mechanism of osteoarthritis and its management using glucosamine formulations. The beneficial effects of glucosamine on the pathophysiology of TMJ osteoarthritis are possibly due to its contribution to hyaluronic acid regulation and in establishing a proper balance between anabolism/catabolism in the articular tissues.

Keywords: Glucosamine; NSAID; TMJ osteoarthritis; anabolism/catabolism.; cartilage; glycosaminoglycans.

PubMed Disclaimer

References

    1. Stegenga B.; de Bont L.G.M.; Boering G.; Osteoarthrosis as the cause of craniomandibular pain and dysfunction: A unifying concept. J Oral Maxillofac Surg 1989,47(3),249-256 - DOI - PubMed
    1. Stegenga B.; De Bont L.G.M.; Boering G.; Van Willigen J.D.; Tissue responses to degenerative changes in the temporomandibular joint: A review. J Oral Maxillofac Surg 1991,49(10),1079-1088 - DOI - PubMed
    1. Gibbs C.H.; Mahan P.E.; Mauderli A.; Lundeen H.C.; Walsh E.K.; Limits of human bite strength. J Prosthet Dent 1986,56(2),226-229 - DOI - PubMed
    1. Helmy E.; Bays R.; Sharawy M.; Osteoarthrosis of the temporomandibular joint following experimental disc perforation in Macaca fascicularis. J Oral Maxillofac Surg 1988,46(11),979-990 - DOI - PubMed
    1. Mills D.K.; Daniel J.C.; Herzog S.; Scapino R.P.; An animal model for studying mechanisms in human temporomandibular joint disc derangement. J Oral Maxillofac Surg 1994,52(12),1279-1292 - DOI - PubMed

MeSH terms