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Review
. 2024 Feb 7;15(3):408-446.
doi: 10.1021/acschemneuro.3c00532. Epub 2024 Jan 12.

Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise

Rumiana Tenchov  1 , Janet M Sasso  1 , Xinmei Wang  1 , Qiongqiong Angela Zhou  1
Affiliations
Review

Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise

Rumiana Tenchov et al. ACS Chem Neurosci. .

Abstract

Aging is typified by a gradual loss of physiological fitness and accumulation of cellular damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging research has a long history throughout civilization, with many efforts put forth to understand and prevent the effects of aging. Multiple strategies aiming to promote healthy aging and extend the lifespan have been developed including lifestyle adjustments, medical treatments, and social programs. A multitude of antiaging medicines and remedies have also been explored. Here, we use data from the CAS Content Collection to analyze the publication landscape of recent research related to antiaging strategies and treatments. We review the recent advances and delineate trends in research headway of antiaging knowledge and practice across time, geography, and development pipelines. We further assess the state-of-the-art antiaging approaches and explore their correlations with age-related diseases. The landscape of antiaging drugs has been outlined and explored. Well-recognized and novel, currently evaluated antiaging agents have also been summarized. Finally, we review clinical applications of antiaging products with their development pipelines. The objective of this review is to summarize current knowledge on preventive strategies and treatment remedies in the field of aging, to outline challenges and evaluate growth opportunities, in order to further efforts to solve the problems that remain.

Keywords: Antiaging strategy; antioxidant; caloric restriction; diet; hormesis; parabiosis; physical exercise; senotherapy.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Timeline of key events and discoveries in antiaging research.−
Figure 2
Figure 2
Yearly growth of the number of documents (journal articles and patents) in the CAS Content Collection related to the antiaging strategies and treatments.
Figure 3
Figure 3
Relationship between antiaging strategies and the hallmarks of aging they counteract.
Figure 4
Figure 4
Top countries with respect to the number of journal articles and patents related to antiaging strategies and treatments.
Figure 5
Figure 5
Flow of patent filings related to aging mechanisms and antiaging strategies from different patent assignee locations (left) to various patent offices of filing (right). The abbreviations on the right indicate the patent offices of China (CN), Korea (KR), Israel (IL), Hong Kong (HK), Argentina (AR), Australia (AU), Russian Federation (RU), United States (US), World Intellectual Property Organization (WO), Taiwan (TW), Mexico (MX), Japan (JP), Canada (CA), Brazil (BR), Austria (AT), European Patent Office (EP), India (IN), Great Britain (GB), Spain (ES), France (FR), Germany (DE), and Italy (IT).
Figure 6
Figure 6
Popular concepts in patents related to aging mechanisms and antiaging strategies according to the CAS Content Collection.
Figure 7
Figure 7
Antiaging strategies explored in the scientific publications: (A) number of publications exploring antiaging strategies; (B) trends in number of publications exploring antiaging strategies during the years 2018–2021.
Figure 8
Figure 8
Correlation of the number of documents related to the hallmarks of aging with the antiaging strategies.
Figure 9
Figure 9
Correlation of the number of documents related to the age-related diseases with the antiaging strategies.
Figure 10
Figure 10
A search in SciFindern for compounds within the 90% similarity limit to quercetin used as an antiaging drug gave 51 compounds. Each column in the figure reflects a single compound, with the top 10 indicated by numbers. The distance between two columns reflects the similarity between these two compounds. The bar height reflects the number of patents related to a given compound. The figure was created using the ChemScape analysis tool of SciFindern. The table on the left lists the top 10 compounds of this collection.
Figure 11
Figure 11
Correlations between exemplary antiaging drugs and (A) hallmarks of aging, and (B) antiaging strategies.
Figure 12
Figure 12
Overall capital raised of (A) venture capital investment and (B) total capital investments for the period 2012–2022 in the antiaging field [$] distributed by regions. Source: PitchBook.com.
Figure 13
Figure 13
Number of therapeutic antiaging clinical trials by year.
Figure 14
Figure 14
Percentage of therapeutic antiaging clinical trials in various phases for the treatment of age-related disease indications: (A) overall antiaging clinical trial phase development; (B) clinical trial phase development for specific age-related diseases.
Figure 15
Figure 15
Percentage of therapeutic antiaging clinical trials in various statuses for the treatment of age-related disease indications.
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