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Review
. 2024 Apr 1;110(4):2288-2299.
doi: 10.1097/JS9.0000000000001068.

A bibliometric analysis of gastric cancer liver metastases: advances in mechanisms of occurrence and treatment options

Chenyuan Wang  1 , Yuzhe Zhang  2 , Ye Zhang  2 , Baifeng Li  3
Affiliations
Review

A bibliometric analysis of gastric cancer liver metastases: advances in mechanisms of occurrence and treatment options

Chenyuan Wang et al. Int J Surg. .

Abstract

Background: Gastric cancer (GC) is the fifth most commonly diagnosed cancer worldwide, and its poor prognosis is predominantly attributed to distant metastasis. The liver is the primary site of GC metastasis. However, there is no universally approved treatment regimen for liver metastasis in GC. The aim of this article is to review the current research status and trends of liver metastasis of GC worldwide.

Methods: The authors utilized the Web of Science Core Collection database to identify articles on liver metastasis from GC published between 2000 and 2022. The authors used bibliometric methods to analyze authors, institutions, countries, journals, and references through CiteSpace and VOSviewer. A total of 1003 articles were included in this study.

Results: Japan published the most articles in the field, followed by China. Nagoya University is the leading institution in the field of liver metastases in GC. Yasuhiro Kodera from Japan has made significant achievements in this area. The authors identified GC to be the most influential journal in this field. Using cluster analysis, the keywords were divided into four major clusters:(1) the molecular mechanism of GC liver metastasis, (2) prognosis, (3) liver resection, and (4) chemotherapy.

Conclusion: Our study systematically summarizes the results of GC liver metastasis research from 2000 to 2022 and describes and predicts research hotspots and trends on a global scale. Research on the molecular mechanisms of GC liver metastasis will become a hot topic in the future, and the expansion of the surgical treatment scope and the advancement of translational therapy will benefit more patients.

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Conflict of interest statement

The authors declare no conflicts of interest.

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

Figures

Figure 1
Figure 1
Detailed flowchart steps of the search strategy in screening publications.
Figure 2
Figure 2
The annual number of publications and citations on gastric cancer with liver metastases from 2000 to 2022.
Figure 3
Figure 3
Co-authorship analysis of the excellent authors in the field of GCLM. (A) A network visualization map. (B) A overlay visualization map. (C) Countries and institutions of these distinguished authors.
Figure 4
Figure 4
The dual-map overlay of journals related to gastric cancer with liver metastases.
Figure 5
Figure 5
The average citation and total publication number of the top 10 journals.
Figure 6
Figure 6
(A) The total number of publications, the average number of citations, visualization map. (B) A network visualization map. (C) A overlay visualization map.
Figure 7
Figure 7
Geographic distribution of global publications on gastric cancer with liver metastases. World map showing the distribution of global publications on gastric cancer with liver metastases.
Figure 8
Figure 8
(A) Bar graph of the top five productive countries/regions. (B) Network visualization map of the top 21 countries’ collaboration. (C) Overlay visualization map.
Figure 9
Figure 9
Density visualization map of the top 51 co-cited references.
Figure 10
Figure 10
(A) A network visualization map. (B) A timeline and keyword clustering display for the GCLM. (C) The top 25 terms with the most significant gastric cancer with liver metastases citation bursts. (D) Keywords that are particularly important in the four groups.
See this image and copyright information in PMC

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