Review
doi: 10.1038/s43588-021-00072-5.
Epub 2021 May 24.
Scaling digital twins from the artisanal to the industrial
Affiliations
- PMID: 38217216
- DOI: 10.1038/s43588-021-00072-5
Item in Clipboard
Review
Scaling digital twins from the artisanal to the industrial
Nat Comput Sci.
2021 May.
Abstract
Mathematical modeling and simulation are moving from being powerful development and analysis tools towards having increased roles in operational monitoring, control and decision support, in which models of specific entities are continually updated in the form of a digital twin. However, current digital twins are largely the result of bespoke technical solutions that are difficult to scale. We discuss two exemplar applications that motivate challenges and opportunities for scaling digital twins, and that underscore potential barriers to wider adoption of this technology.
© 2021. Springer Nature America, Inc.
Similar articles
-
Using the Non-Adoption, Abandonment, Scale-Up, Spread, and Sustainability (NASSS) Framework to Identify Barriers and Facilitators for the Implementation of Digital Twins in Cardiovascular Medicine.Sensors (Basel). 2023 Jul 12;23(14):6333. doi: 10.3390/s23146333. Sensors (Basel). 2023. PMID: 37514627 Free PMC article.
-
Integrating mechanism-based modeling with biomedical imaging to build practical digital twins for clinical oncology.Biophys Rev (Melville). 2022 Jun;3(2):021304. doi: 10.1063/5.0086789. Epub 2022 May 17. Biophys Rev (Melville). 2022. PMID: 35602761 Free PMC article. Review.
-
Digital Twins in Healthcare: Methodological Challenges and Opportunities.J Pers Med. 2023 Oct 23;13(10):1522. doi: 10.3390/jpm13101522. J Pers Med. 2023. PMID: 37888133 Free PMC article. Review.
-
Unlocking the potentials of digital twins for optimal healthcare delivery in Africa.Oxf Open Digit Health. 2024 Sep 16;2:oqae039. doi: 10.1093/oodh/oqae039. eCollection 2024. Oxf Open Digit Health. 2024. PMID: 40230959 Free PMC article.
-
From virtual to reality: innovative practices of digital twins in tumor therapy.J Transl Med. 2025 Mar 19;23(1):348. doi: 10.1186/s12967-025-06371-z. J Transl Med. 2025. PMID: 40108714 Free PMC article. Review.
Cited by
-
Convergence, sampling and total order estimator effects on parameter orthogonality in global sensitivity analysis.PLoS Comput Biol. 2024 Jul 17;20(7):e1011946. doi: 10.1371/journal.pcbi.1011946. eCollection 2024 Jul. PLoS Comput Biol. 2024. PMID: 39018334 Free PMC article.
-
A global sensitivity analysis of a mechanistic model of neoadjuvant chemotherapy for triple negative breast cancer constrained by in vitro and in vivo imaging data.Eng Comput. 2024;40(3):1469-1499. doi: 10.1007/s00366-023-01873-0. Epub 2023 Aug 7. Eng Comput. 2024. PMID: 39620056 Free PMC article.
-
Digital twin assisted surgery, concept, opportunities, and challenges.NPJ Digit Med. 2025 Jan 15;8(1):32. doi: 10.1038/s41746-024-01413-0. NPJ Digit Med. 2025. PMID: 39815013 Free PMC article. Review.
-
Linking scientific instruments and computation: Patterns, technologies, and experiences.Patterns (N Y). 2022 Oct 14;3(10):100606. doi: 10.1016/j.patter.2022.100606. eCollection 2022 Oct 14. Patterns (N Y). 2022. PMID: 36277824 Free PMC article.
-
Digital twins and the future of precision mental health.Front Psychiatry. 2023 Mar 13;14:1082598. doi: 10.3389/fpsyt.2023.1082598. eCollection 2023. Front Psychiatry. 2023. PMID: 36993921 Free PMC article.
References
-
- Digital Twin: Definition & Value. AIAA Position Paper (AIAA Digital Engineering Integration Committee, 2020).
-
- Bruynseels, K., Santoni de Sio, F. & van den Hoven, J. Digital twins in health care: ethical implications of an emerging engineering paradigm. Front. Genet. 9, 31 (2018). - DOI
-
- Corral-Acero, J. et al. The ‘digital twin’ to enable the vision of precision cardiology. Eur. Heart J. 41, 4556–4564 (2020).
-
- Tao, F., Zhang, H., Liu, A. & Nee, A. Y. Digital twin in industry: state-of-the-art. IEEE Trans. Industr. Inform. 15, 2405–2415 (2018). - DOI
-
- Wagg, D., Worden, K., Barthorpe, R. & Gardner, P. Digital twins: state-of-the-art and future directions for modeling and simulation in engineering dynamics applications. ASME J. Risk Uncertainty B 6, 030901 (2020).
Publication types
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
