doi: 10.1128/mcb.7.2.921-924.1987.
Characterization of the rearranged tpr-met oncogene breakpoint
- PMID: 3821733
- PMCID: PMC365151
- DOI: 10.1128/mcb.7.2.921-924.1987
Item in Clipboard
Characterization of the rearranged tpr-met oncogene breakpoint
Mol Cell Biol.
1987 Feb.
Abstract
We determined the nucleotide sequence of the rearranged trp-met genomic locus and the corresponding portions of the unrearranged tpr and met genomic fragments. The breakpoints occur at one end of a stretch of 21 A residues that follow an Alu repetitive sequence in the tpr locus and within a group of 3 A residues in the met proto-oncogene locus. We conclude that the fusion between the tpr locus on chromosome 1 and the met locus on chromosome 7 resulted from a recombination event.
Similar articles
-
Analysis by pulsed field gel electrophoresis reveals complex rearrangements in two MET alleles in a chemically-treated human cell line, MNNG-HOS.Oncogene. 1990 Oct;5(10):1565-71. Oncogene. 1990. PMID: 2250912
-
Two rearranged MET alleles in MNNG-HOS cells reveal the orientation of MET on chromosome 7 to other markers tightly linked to the cystic fibrosis locus.Proc Natl Acad Sci U S A. 1988 Apr;85(8):2667-71. doi: 10.1073/pnas.85.8.2667. Proc Natl Acad Sci U S A. 1988. PMID: 3282234 Free PMC article.
-
TPR-MET oncogenic rearrangement: detection by polymerase chain reaction amplification of the transcript and expression in human tumor cell lines.Proc Natl Acad Sci U S A. 1990 Jan;87(2):738-42. doi: 10.1073/pnas.87.2.738. Proc Natl Acad Sci U S A. 1990. PMID: 2300559 Free PMC article.
-
Oncogene activation by chromosomal rearrangement in chronic myelocytic leukemia.Mutat Res. 1987 Sep;186(2):161-72. doi: 10.1016/0165-1110(87)90029-7. Mutat Res. 1987. PMID: 3306360 Review.
-
The human met oncogene is a member of the tyrosine kinase family.Princess Takamatsu Symp. 1986;17:221-32. Princess Takamatsu Symp. 1986. PMID: 3332011 Review.
Cited by
-
Compilation of DNA strand exchange sites for non-homologous recombination in somatic cells.Nucleic Acids Res. 1988 Mar 11;16(5):1739-58. doi: 10.1093/nar/16.5.1739. Nucleic Acids Res. 1988. PMID: 2832826 Free PMC article.
-
Biology of MET: a double life between normal tissue repair and tumor progression.Ann Transl Med. 2015 Apr;3(6):82. doi: 10.3978/j.issn.2305-5839.2015.03.58. Ann Transl Med. 2015. PMID: 25992381 Free PMC article. Review.
-
Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.Proc Natl Acad Sci U S A. 1987 Sep;84(18):6379-83. doi: 10.1073/pnas.84.18.6379. Proc Natl Acad Sci U S A. 1987. PMID: 2819873 Free PMC article.
-
Anti-Differentiation Effect of Oncogenic Met Receptor in Terminally-Differentiated Myotubes.Biomedicines. 2015 Feb 12;3(1):124-137. doi: 10.3390/biomedicines3010124. Biomedicines. 2015. PMID: 28536403 Free PMC article.
-
Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development.J Cell Biol. 1993 Oct;123(1):223-35. doi: 10.1083/jcb.123.1.223. J Cell Biol. 1993. PMID: 8408200 Free PMC article.
References
Publication types
MeSH terms
Substances
Associated data
- Actions
- Actions
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous
