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. 2024 Jan 13;28(1):89.
doi: 10.1007/s00784-023-05480-7.

Assessing bone formation on hydrophilic and hydrophobic implant surfaces in a murine model treated with bisphosphonates

Julio Cesar Sánchez-Puetate  1 , Bruno Luís Graciliano Silva  1 , Felipe Eduardo Pinotti  1 , Camila Chierici Marcantonio  1 , Guilherme José Pimentel Lopes de Oliveira  2 , Elcio Marcantonio Junior  1 , Rosemary Adriana Chierici Marcantonio  3
Affiliations

Assessing bone formation on hydrophilic and hydrophobic implant surfaces in a murine model treated with bisphosphonates

Julio Cesar Sánchez-Puetate et al. Clin Oral Investig. .

Abstract

Objective: To evaluate the osseointegration of implants with hydrophobic (HFB) and hydrophilic (HFL) surfaces in a murine model of high-dose bisphosphonates (BPs).

Materials and methods: Sixty-four rats were randomly allocated into four groups: control group with HFB implants (CG-HFB), control group with HFL implants (CG-HFL), BP group with HFB implants (BP-HFB), and BP group with HFL implants (BP-HFL). Animals were euthanized after 15 and 45 days (n=8). The dependent variables assessed were the removal torque (biomechanical analysis), the bone volume around the implants (%BV/TV) (microtomographic analysis), the bone-implant contact (%BIC), the bone between the threads (%BBT) (histomorphometric analysis), and the expression of bone metabolism markers (immunohistochemistry analysis).

Results: The CG-HFL and BP-HFL groups presented higher removal torque than the CG-HFB and BP-HFB implants. The %BIC of the CG-HFL surfaces was slightly higher than that of the CG-HFB implants. The BP-HFB and BP-HFL groups presented a higher %BIC than that of the CG-HFB and CG-HFL groups (p<0.001). BP therapy also increased the %BBT at both implant surfaces. Higher levels of ALP were observed in the matrix region of bone tissue on the HFL surfaces than on the HFB surfaces.

Conclusion: Both surfaces enable osseointegration in rats under BP therapy.

Clinical relevance: The study demonstrates that hydrophobic (HFB) and hydrophilic (HFL) implant surfaces can promote osseointegration in rats undergoing bisphosphonate therapy. The HFL surfaces exhibited improved biomechanical performance, higher bone-implant contact, and increased bone volume, suggesting their potential clinical relevance for implant success in individuals on bisphosphonate treatment.

Keywords: Bisphosphonates; Dental implants; Osseointegration; Surface properties.

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References

    1. Bosshardt DD, Chappuis V, Buser D (2017) Osseointegration of titanium, titanium alloy and zirconia dental implants: current knowledge and open questions. Periodontol 73:22–40. https://doi.org/10.1111/prd.12179 - DOI
    1. Lane NE (2006) Epidemiology, etiology, and diagnosis of osteoporosis. Am J Obstet Gynecol 194:S3–S11. https://doi.org/10.1016/j.ajog.2005.08.047 - DOI - PubMed
    1. Tolia M, Zygogianni A, Kouvaris JR, Meristoudis C, Margari N, Karakitsos P, Kokakis I, Kardamakis D, Papadimitriou C, Mystakidou K, Tsoukalas N, Kyrgias G, Armonis B, Filippiadis DK, Kelekis AD, Kelekis N, Kouloulias V (2014) The key role of bisphosphonates in the supportive care of cancer patients. Anticancer Res 34:23–37 - PubMed
    1. Conte Neto N, Spolidorio LC, Andrade CR, Bastos AS, Guimaraes M, Marcantonio E Jr (2013) Experimental development of bisphosphonate-related osteonecrosis of the jaws in rodents. Int J Exp Pathol 94:65–73. https://doi.org/10.1111/iep.12007 - DOI - PubMed - PMC
    1. Tella SH, Gallagher JC (2014) Prevention and treatment of postmenopausal osteoporosis. J Steroid Biochem Mol Biol 142:155–170. https://doi.org/10.1016/j.jsbmb.2013.09.008 - DOI - PubMed

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