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Review
. 2024 Nov;479(11):2895-2906.
doi: 10.1007/s11010-023-04904-y. Epub 2024 Jan 13.

Long-chain polyunsaturated fatty acids influence colorectal cancer progression via the interactions between the intestinal microflora and the macrophages

Duo Peng #  1   2 , Yan Wang #  1   3 , Yunhong Yao #  1   4 , Zisha Yang  2 , Shuang Wu  4 , Kaijing Zeng  4 , Xinrong Hu  5   6 , Yi Zhao  7   8   9
Affiliations
Review

Long-chain polyunsaturated fatty acids influence colorectal cancer progression via the interactions between the intestinal microflora and the macrophages

Duo Peng et al. Mol Cell Biochem. 2024 Nov.

Abstract

The metabolism of long-chain polyunsaturated fatty acids (LCPUFAs) is closely associated with the risk and progression of colorectal cancer (CRC). This paper aims to investigate the role of LCPUFA in the crosstalk between intestinal microflora and macrophages, as well as the effects of these three parties on the progression of CRC. The metabolism and function of LCPUFA play important roles in regulating the composition of the human gut microflora and participating in the regulation of inflammation, ultimately affecting macrophage function and polarization, which is crucial in the tumor microenvironment. The effects of LCPUFA on cellular interactions between the two species can ultimately influence the progression of CRC. In this review, we explore the molecular mechanisms and clinical applications of LCPUFA in the interactions between intestinal microflora and intestinal macrophages, as well as its significance for CRC progression. Furthermore, we reveal the role of LCPUFA in the construction of the CRC microenvironment and explore the key nodes of the interactions between intestinal flora and intestinal macrophages in the environment. It provides potential targets for the metabolic diagnosis and treatment of CRC.

Keywords: Colorectal cancer; Intestinal microflora; Long-chain polyunsaturated fatty acids; Macrophages; Metabolism.

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