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Randomized Controlled Trial
. 2024 Feb;38(2):108669.
doi: 10.1016/j.jdiacomp.2023.108669. Epub 2023 Dec 29.

Prevalence and predictors of erectile dysfunction among men in the diabetes prevention program outcomes study

Yooni A Blair  1 , Lindsay Doherty  2 , Marinella Temprosa  2 , Rodica Pop-Busui  3 , Kishore M Gadde  4 , Prachi Singh  5 , Arthur H Owora  6 , Hunter Wessells  7 , Aruna V Sarma  8 ; Diabetes Prevention Program Research Group
Affiliations
Randomized Controlled Trial

Prevalence and predictors of erectile dysfunction among men in the diabetes prevention program outcomes study

Yooni A Blair et al. J Diabetes Complications. 2024 Feb.

Abstract

Objective: To determine burden and identify correlates of erectile dysfunction (ED) among men with prediabetes (PreD) and type 2 diabetes (T2D) enrolled in the Diabetes Prevention Program (DPP) Outcomes Study (DPPOS).

Research design and methods: The 2017 DPPOS visit included administration of the International Index of Erectile Function. Of 648 male participants, 88 % (n = 568) completed the survey. Associations between sociodemographic, behavioral, clinical, and glycemic measures at time of ED assessment, and ED were examined using multivariable logistic regression models in men with PreD and T2D separately.

Results: Overall, 218 (38 %) men met ED criteria. Prevalence was similar in men with PreD (41 %) and T2D (37 %) (p = 0.4). In all men, age (p < 0.001) increased odds of ED. Among men with PreD, those assigned to intensive lifestyle intervention (ILS), but not metformin, had decreased odds of ED compared with the placebo group (OR = 0.35, 95 % CI = 0.13, 0.94). Non-Hispanic White race was associated with increased odds of ED compared with other races (OR = 4.3; 95 % CI = 1.92, 9.65). Among men with T2D, ED risk did not differ by DPP treatment assignment; however, individuals with metabolic syndrome defined by National Cholesterol Education Program criteria, had increased odds of ED (OR = 1.85, 95 % CI = 1.14, 3.01), as did individuals with depression (OR = 2.05; 95 % CI = 1.10, 3.79).

Conclusions: ED is prevalent in men with PreD and T2D. Our finding of reduced odds of ED in men randomized to ILS and with PreD suggests a potential opportunity for risk mitigation in the prediabetes interval. In men who have progressed to T2D, metabolic factors appear to be associated with ED.

Keywords: Diabetes; Erectile dysfunction; Prediabetes.

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Conflict of interest statement

Declaration of competing interest No conflicts of interest.

Figures

Figure 1.
Figure 1.
Distribution of Responses to ED Single Item Proxy Overall and by Diabetes Status * 9 (1.6%) additional participants added to cohort of participants with ED based on criteria of PDE5-Inhibitor use
See this image and copyright information in PMC

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