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. 2024 Mar;38(3):254-267.
doi: 10.1111/ppe.13043. Epub 2024 Jan 14.

Assessing cardiovascular disease risk in women with a history of hypertensive disorders of pregnancy: A guidance paper for studies using administrative data

Amy Johnston  1   2 , Graeme N Smith  3 , Peter Tanuseputro  4   5   6 , Thais Coutinho  7 , Jodi D Edwards  1   2   4
Affiliations

Assessing cardiovascular disease risk in women with a history of hypertensive disorders of pregnancy: A guidance paper for studies using administrative data

Amy Johnston et al. Paediatr Perinat Epidemiol. 2024 Mar.

Abstract

Background: Hypertensive disorders of pregnancy (HDP) are a major cause of maternal morbidity and mortality, and their association with increased cardiovascular disease (CVD) risk represents a major public health concern. However, assessing CVD risk in women with a history of these conditions presents unique challenges, especially when studies are carried out using routinely collected data.

Objectives: To summarise and describe key challenges related to the design and conduct of administrative studies assessing CVD risk in women with a history of HDP and provide concrete recommendations for addressing them in future research.

Methods: This is a methodological guidance paper.

Results: Several conceptual and methodological factors related to the data-generating mechanism and study conceptualisation, design/data management and analysis, as well as the interpretation and reporting of study findings should be considered and addressed when designing and carrying out administrative studies on this topic. Researchers should develop an a priori conceptual framework within which the research question is articulated, important study variables are identified and their interrelationships are carefully considered.

Conclusions: To advance our understanding of CVD risk in women with a history of HDP, future studies should carefully consider and address the conceptual and methodological considerations outlined in this guidance paper. In highlighting these challenges, and providing specific recommendations for how to address them, our goal is to improve the quality of research carried out on this topic.

Keywords: cardiovascular disease; epidemiology; hypertensive disorders of pregnancy; research methodology; routinely collected health data.

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References

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