Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023;64(12):1519-1522.
doi: 10.11406/rinketsu.64.1519.

[Characteristics of myelodysplastic syndromes with der(1;7)(q10;p10)]

[Article in Japanese]
Rurika Okuda  1
Affiliations
Review

[Characteristics of myelodysplastic syndromes with der(1;7)(q10;p10)]

[Article in Japanese]
Rurika Okuda. Rinsho Ketsueki. 2023.

Abstract

der(1;7)(q10;p10) is a derivative chromosome generated by an unbalanced translocation between chromosomes 1 and 7 during DNA replication. It was first described in 1980, over 40 years ago, in a case report of three patients with myelofibrosis and myeloid metaplasia. This unbalanced translocation has been identified as a characteristic entity within myeloid neoplasms. Recent clinical and genetic studies comparing der(1;7)(q10;p10)(+) against -7/del(7q) have revealed that patients with der(1;7)(q10;p10)(+) MDS have a better prognosis and a unique mutational profile. This review discusses the clinical and genetic features of der(1;7)(q10;p10)(+) myeloid neoplasms.

Keywords: Myelodysplastic syndromes; der(1;7)(q10;p10).

PubMed Disclaimer

MeSH terms