Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Mar;37(3):359-63.
doi: 10.1212/wnl.37.3.359.

Dementia of the Alzheimer type: clinical and family study of 22 twin pairs

L E Nee, R Eldridge, T Sunderland, C B Thomas, D Katz, K E Thompson, H Weingartner, H Weiss, C Julian, R Cohen

Dementia of the Alzheimer type: clinical and family study of 22 twin pairs

L E Nee et al. Neurology. 1987 Mar.

Abstract

We studied 22 twin pairs in which one or both twins had dementia of the Alzheimer type (DAT). In four twins, diagnosis was confirmed by autopsy. Seven monozygotic (MZ) pairs were concordant for DAT; 10 MZ pairs were discordant. Two dizygotic (DZ) pairs were concordant for DAT, and 3 DZ pairs were discordant. The current concordance rate was 41% for MZ twins and 40% for DZ twins. The study supports the belief that, etiologically, DAT cannot be entirely accounted for by a single autosomal dominant gene. The data also suggest that in certain genetic circumstances, disease expression may be delayed in females.

PubMed Disclaimer

LinkOut - more resources