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. 2023 Dec 27:50:101332.
doi: 10.1016/j.ijcha.2023.101332. eCollection 2024 Feb.

Doxorubicin-induced cardiotoxicity and risk factors

Carl Belger  1 , Carmelita Abrahams  1 , Aqeela Imamdin  1 , Sandrine Lecour  1
Affiliations

Doxorubicin-induced cardiotoxicity and risk factors

Carl Belger et al. Int J Cardiol Heart Vasc. .

Abstract

Doxorubicin (DOX) is an anthracycline antibiotic widely used as a chemotherapeutic agent to treat solid tumours and hematologic malignancies. Although useful in the treatment of cancers, the benefit of DOX is limited due to its cardiotoxic effect that is observed in a large number of patients. In the literature, there is evidence that the presence of various factors may increase the risk of developing DOX-induced cardiotoxicity. A better understanding of the role of these different factors in DOX-induced cardiotoxicity may facilitate the choice of the therapeutic approach in cancer patients suffering from various cardiovascular risk factors. In this review, we therefore discuss the latest findings in both preclinical and clinical research suggesting a link between DOX-induced cardiotoxicity and various risk factors including sex, age, ethnicity, diabetes, dyslipidaemia, obesity, hypertension, cardiovascular disease and co-medications.

Keywords: Cardiovascular risk; Chemotherapy; Diabetes; Doxorubicin; Toxicity.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Major risk factors for DOX-induced cardiotoxicity. Abbreviations: ACE = Angiotensin Converting Enzyme, ARB = Angiotensin Receptor Blockers, CCB = Calcium Channel Blockers, DOX = Doxorubicin, MRT = Mediastinal Radiation Therapy, ROS = Reactive Oxygen Species, SGLT2 = Sodium Glucose Transporter 2.
Fig. 2
Fig. 2
Signalling pathways targeted by different risk factors in DOX-induced cardiotoxicity.
See this image and copyright information in PMC

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