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. 1987 Jan 14;73(2):192-6.
doi: 10.1016/0304-3940(87)90016-4.

A disorder of cortical GABAergic innervation in Alzheimer's disease

J Hardy, R Cowburn, A Barton, G Reynolds, P Dodd, P Wester, A M O'Carroll, E Lofdahl, B Winblad

A disorder of cortical GABAergic innervation in Alzheimer's disease

J Hardy et al. Neurosci Lett. .

Abstract

Synaptosomal gamma-aminobutyric acid (GABA) uptake has been used as a biochemical marker for GABAergic terminals in controls and Alzheimer disease brains. Use of this marker suggests a large (ca. 70%) loss of cortical and hippocampal GABA terminals in Alzheimer brain. To explain this observation we suggest that neuron loss in this disorder occurs via a process of cortical retrograde degeneration. This scheme reconciles our findings with previous neurochemical measurements on Alzheimer disease brains and also better reconciles the biochemistry with the histology of the disorder.

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