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. 2023 Jun;23(2):179-185.
doi: 10.4314/ahs.v23i2.19.

Correlation between vaginal flora and cervical immune function of human papilloma virus-infected patients with cervical cancer

Qiang Wang  1 , Wenmin Qin  2 , Wei Gao  1 , Kai Zhao  2 , Xiaohong Pan  2 , Xiaofei Jiang  2 , Juan Zhao  2
Affiliations

Correlation between vaginal flora and cervical immune function of human papilloma virus-infected patients with cervical cancer

Qiang Wang et al. Afr Health Sci. 2023 Jun.

Abstract

Background: To analyse the correlation between vaginal flora and cervical immune function of HPV-infected patients with cervical cancer.

Methods: Six hundred females with genital tract infections treated in Xuzhou Hospital of Traditional Chinese Medicine from January 2014 to December 2016 were selected and divided into a high-risk HPV group (n=246) and a control group (n=354). The vaginal flora and human T lymphocyte subsets (CD3+, CD4+, CD8+) were detected. Multivariate logistic regression analysis was performed to explore the risk factors for HPV infection.

Results: The numbers of CD4+ and CD4+/CD8+ T cells of the high-risk HPV group were significantly lower than those of the control group (P<0.05). The two groups had similar numbers of CD3+ and CD8+ T cells. In the high-risk HPV group, the positive rates of Lactobacillus, Chlamydia trachomatis, Mycoplasma hominis, mycetes, Ureaplasma urealyticum and bacterial vaginosis were significantly higher than those of the control group (P<0.05). There was no significant difference in the positive rates of trichomonads between the two groups. Multivariate logistic regression analysis revealed that C. trachomatis and U. urealyticum were independent risk factors for high-risk HPV infection (P<0.05).

Conclusion: High-risk HPV infection in patients with cervical cancer was associated with vaginal flora and immune function. C. trachomatis and U. urealyticum were independent risk factors for high-risk HPV infection.

Keywords: Cervical cancer; human papilloma virus; immune function; vaginal flora.

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Conflict of interest statement

The authors report no conflicts of interest.

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References

    1. Pytynia KB, Dahlstrom KR, Sturgis EM. Epidemiology of HPV-associated oropharyngeal cancer. Oral Oncol. 2014;50(5):380–386. - PMC - PubMed
    1. Guerrero-Preston R, Godoy-Vitorino F, Jedlicka A, Rodríguez-Hilario A, González H, Bondy J, et al. 16S rRNA amplicon sequencing identifies microbiota associated with oral cancer, human papilloma virus infection and surgical treatment. Oncotarget. 2016;7(32):51320–51334. - PMC - PubMed
    1. Youssef MA, Abdelsalam L, Harfoush RA, Talaat IM, Elkattan E, Mohey A, et al. Prevalence of human papilloma virus (HPV) and its genotypes in cervical specimens of Egyptian women by linear array HPV genotyping test. Infect Agent Cancer. 2016;11:6. - PMC - PubMed
    1. Hikiami R, Yamakado H, Tatsumi S, Ayaki T, Hashi Y, Yamashita H, et al. Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report of a 15-year-old Girl. Intern Med. 2018;57(13):1917–1919. - PMC - PubMed
    1. Gao W, Weng J, Gao Y, Chen X. Comparison of the vaginal microbiota diversity of women with and without human papillomavirus infection: a cross-sectional study. BMC Infect Dis. 2013;13:271. - PMC - PubMed