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. 2023 Jun;23(2):553-564.
doi: 10.4314/ahs.v23i2.64.

Pulmonary artery diameter and NT-proBNP in patients with Covid-19: Predicting prognosis and mortality

Mercan Tastemur  1 , Esin Olcucuoğlu  2 , Gunes Arik  1 , Ihsan Ates  3 , Kamile Silay  1
Affiliations

Pulmonary artery diameter and NT-proBNP in patients with Covid-19: Predicting prognosis and mortality

Mercan Tastemur et al. Afr Health Sci. 2023 Jun.

Abstract

Background: The diverse and complex presentations of COVID-19 continue to impact the world. Factors related to prognosis and mortality are still not fully illuminated.

Objectives: We aimed to asses the relationship of N-terminal pro B-type natriuretic peptide (NT-proBNP) and main pulmonary artery diameter (MPAD) with COVID-19 prognosis and mortality.

Methods: 152 COVID-19 patients over the age of 18, were included in the study. Thoracic CT, NT-proBNP values, laboratory and demographic data of these patients were obtained by retrospectively examining the patient files and scanning the results through the patient registry.

Results: According to multivariate logistic regression (LR) analysis, high NT-proBNP level (OR=3.542; 95% CI=1.745-9.463; p=0.021) and MPAD/ascending aortic diameter (AAD) ratio>0.75 (OR=2.692; 95% CI=1.264-9.312; p=0.036) were determined as independent risk factors predicting mortality in COVID-19 patients. A significant positive correlation was observed between NT-proBNP level and MPA diameter (r=0.296, p<0.001). The cut-off value was measured as 27.5 mm for MPA diameter and 742 pg/ml for NT-proBNP.

Conclusions: Accurate and effective interpretation of available radiological and laboratory data is essential to reveal the factors predicting prognosis and mortality in COVID-19. In this study,we evaluated that the thorax CTs and determined that the MPAD/AAD and NT-proBNP level were independent risk factors in predicting mortality.

Keywords: COVID-19; MPAD/AAD ratio; NT-proBNP; Pulmonary artery diameter.

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Figures

None
Picture 1
Figure 1
Figure 1
ROC curve evaluating the effectiveness of main pulmonary artery diameter in predicting mortality in COVID-19 patients
Figure 2
Figure 2
ROC curve evaluating the effectiveness of the main pulmonary artery/ascending aorta diameter ratio in predicting mortality in COVID-19 patients
Figure 3
Figure 3
ROC curve evaluating the effectiveness of NT-proBNP level in predicting mortality in COVID-19 patients
See this image and copyright information in PMC

References

    1. Gao Z, Xu Y, Sun C, Wang X, Guo Y, Qiu S, et al. A systematic review of asymptomatic infections with COVID-19. J Microbiol Immunol Infect. 2021;54(1):12–16. - PMC - PubMed
    1. Medicine JHU, author. Johns Hopkins Coronavirus Resource Center. 2022. https://coronavirus.jhu.edu/
    1. Waller JV, Kaur P, Tucker A, Lin KK, Diaz MJ, Henry TS, et al. Diagnostic Tools for Coronavirus Disease (COVID-19): Comparing CT and RT-PCR Viral Nucleic Acid Testing. AJR Am J Roentgenol. 2020;215(4):834–838. - PubMed
    1. Ye Z, Zhang Y, Wang Y, Huang Z, Song B. Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review. Eur Radiol. 2020;30(8):4381–4389. - PMC - PubMed
    1. Alsharif W, Qurashi A. Effectiveness of COVID-19 diagnosis and management tools: A review. Radiography (Lond) 2021;27(2):682–687. - PMC - PubMed