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Review
. 2024 Apr;22(4):206-225.
doi: 10.1038/s41579-023-01003-z. Epub 2024 Jan 15.

SARS-CoV-2 biology and host interactions

Silvio Steiner  1   2 , Annika Kratzel  1   2 , G Tuba Barut  1   2 , Reto M Lang  1   2   3 , Etori Aguiar Moreira  1   2 , Lisa Thomann  1   2 , Jenna N Kelly  1   2   4   5 , Volker Thiel  6   7   8   9
Affiliations
Review

SARS-CoV-2 biology and host interactions

Silvio Steiner et al. Nat Rev Microbiol. 2024 Apr.

Abstract

The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected our society. The rapid spread and continuous evolution of new SARS-CoV-2 variants continue to threaten global public health. Recent scientific advances have dissected many of the molecular and cellular mechanisms involved in coronavirus infections, and large-scale screens have uncovered novel host-cell factors that are vitally important for the virus life cycle. In this Review, we provide an updated summary of the SARS-CoV-2 life cycle, gene function and virus-host interactions, including recent landmark findings on general aspects of coronavirus biology and newly discovered host factors necessary for virus replication.

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References

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