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Review
. 2024 Mar;48(3):280-289.
doi: 10.1002/cbin.12122. Epub 2024 Jan 15.

The role of exo-miRNA in diagnosis and treatment of cancers, focusing on effective miRNAs in colorectal cancer

Hamzah H Kzar Al-Shukri  1 , Sana Abdul-Jabbar Ali  2 , Karam Akram Al-Akkam  2 , Ahmed Hjazi  3 , Irodakhon Rasulova  4   5 , Yasser Fakri Mustafa  6 , Dahlia N Al-Saidi  7 , Mohammed Qasim Alasheqi  8 , Ahmed Alawadi  9   10   11 , Ali Alsaalamy  12
Affiliations
Review

The role of exo-miRNA in diagnosis and treatment of cancers, focusing on effective miRNAs in colorectal cancer

Hamzah H Kzar Al-Shukri et al. Cell Biol Int. 2024 Mar.

Abstract

Small extracellular (EV) particles known as exosomes are released by a variety of cell types, including immune system cells, stem cells, and tumor cells. They are regarded as a subgroup of EVs and have a diameter that ranges from 30 to 150 nm. Proteins, lipids, nucleic acids (including RNA and DNA), and different bioactive compounds are among the wide range of biomolecules that make up the cargo of exosomes. Exosomes are crucial for intercellular communication because they let cells share information and signaling chemicals. They are involved in various physiological and pathological processes, including immune responses, tissue regeneration, cancer progression, and neurodegenerative diseases. In conclusion, it is essential to continue research into exosome-based cancer medicines to advance understanding, improve treatment plans, create personalized tactics, ensure safety, and speed up clinical translation.

Keywords: cancer; exosome; extracellular vesicles (EVs); therapeutic approaches.

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References

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