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. 2024 Jan;39(1):25-33.
doi: 10.3904/kjim.2023.393. Epub 2024 Jan 1.

Biomarkers of the relationship of particulate matter exposure with the progression of chronic respiratory diseases

Junghyun Kim  1 , Soo Jie Chung  1 , Woo Jin Kim  2   3
Affiliations

Biomarkers of the relationship of particulate matter exposure with the progression of chronic respiratory diseases

Junghyun Kim et al. Korean J Intern Med. 2024 Jan.

Abstract

A high level of particulate matter (PM) in air is correlated with the onset and development of chronic respiratory diseases. We conducted a systematic literature review, searching the MEDLINE, EMBASE, and Cochrane databases for studies of biomarkers of the effect of PM exposure on chronic respiratory diseases and the progression thereof. Thirty-eight articles on biomarkers of the progression of chronic respiratory diseases after exposure to PM were identified, four of which were eligible for review. Serum, sputum, urine, and exhaled breath condensate biomarkers of the effect of PM exposure on chronic obstructive pulmonary disease (COPD) and asthma had a variety of underlying mechanisms. We summarized the functions of biomarkers linked to COPD and asthma and their biological plausibility. We identified few biomarkers of PM exposure-related progression of chronic respiratory diseases. The included studies were restricted to those on biomarkers of the relationship of PM exposure with the progression of chronic respiratory diseases. The predictive power of biomarkers of the effect of PM exposure on chronic respiratory diseases varies according to the functions of the biomarkers.

Keywords: Asthma; Biomarkers; Lung diseases; Particulate matter; Pulmonary disease, chronic obstructive.

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Conflict of interest statement

Conflicts of interest

The authors disclose no conflicts.

Figures

Figure 1
Figure 1
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram.
Figure 2
Figure 2
Risk of bias of the included studies according to the judgement of the authors.
See this image and copyright information in PMC

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