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. 2024 Jan;103(1):e15297.
doi: 10.1111/tan.15297.

Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival

Tineke Kardol-Hoefnagel  1 , Danial Mohammadi Senejohnny  1 , Elena G Kamburova  1 , Bram W Wisse  1 , Maartje L Gruijters  2 , Irma Joosten  3 , Wil A Allebes  3 , Arnold van der Meer  3 , Luuk B Hilbrands  4 , Marije C Baas  4 , Eric Spierings  1   5 , Cornelis E Hack  1 , Franka E van Reekum  6 , Arjan D van Zuilen  6 , Marianne C Verhaar  6 , Adriaan C A D Drop  1 , Loes Plaisier  1 , Rowena C A Melchers  1 , Marc A J Seelen  7 , Jan Stephan Sanders  7 , Bouke G Hepkema  8 , Bart-Jan Kroesen  8 , Laura B Bungener  8 , Caroline Roozendaal  8 , Marcel G J Tilanus  9 , Christina E Voorter  9 , Lotte Wieten  9 , Elly M van Duijnhoven  10 , Mariëlle A C J Gelens  10 , Maarten H L Christiaans  10 , Frans J van Ittersum  11 , Shaikh A Nurmohamed  11 , Neubury M Lardy  12 , Wendy Swelsen  12 , Karlijn A M I van der Pant  2 , Neelke C van der Weerd  2 , Ineke J M Ten Berge  2 , Andries Hoitsma  13 , Paul J M van der Boog  14 , Johan W de Fijter  14 , Michiel G H Betjes  15 , Dave L Roelen  16 , Frans H Claas  16 , Frederike J Bemelman  2 , Sebastiaan Heidt  16 , Henny G Otten  1   5
Affiliations

Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival

Tineke Kardol-Hoefnagel et al. HLA. 2024 Jan.

Abstract

In kidney transplantation, donor HLA antibodies are a risk factor for graft loss. Accessibility of donor eplets for HLA antibodies is predicted by the ElliPro score. The clinical usefulness of those scores in relation to transplant outcome is unknown. In a large Dutch kidney transplant cohort, Ellipro scores of pretransplant donor antibodies that can be assigned to known eplets (donor epitope specific HLA antibodies [DESAs]) were compared between early graft failure and long surviving deceased donor transplants. We did not observe a significant Ellipro score difference between the two cohorts, nor significant differences in graft survival between transplants with DESAs having high versus low total Ellipro scores. We conclude that Ellipro scores cannot be used to identify DESAs associated with early versus late kidney graft loss in deceased donor transplants.

Keywords: DESA; Ellipro scores; kidney transplantation.

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References

REFERENCES

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