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. 2024 Apr;34(4):374-376.
doi: 10.1111/pan.14839. Epub 2024 Jan 16.

Hyperammonemia is associated with reduced objective anesthetic requirements in children: A retrospective case-control study

Vikas N O'Reilly-Shah  1 , Wil Van Cleve  1 , Andrew Walters  1 , Agnes I Hunyady  1 , Philip G Morgan  1 , Li Li  1 , David M Polaner  1
Affiliations

Hyperammonemia is associated with reduced objective anesthetic requirements in children: A retrospective case-control study

Vikas N O'Reilly-Shah et al. Paediatr Anaesth. 2024 Apr.
No abstract available

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References

REFERENCES

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    1. Brosnan RJ, Yang L, Milutinovic PS, et al. Ammonia has anesthetic properties. Anesth Analg. 2007;104(6):1430-1433. doi:10.1213/01.ane.0000264072.97705.0f
    1. Mishra S, Welch N, Karthikeyan M, et al. Dysregulated cellular redox status during hyperammonemia causes mitochondrial dysfunction and senescence by inhibiting sirtuin-mediated deacetylation. Aging Cell. 2023;22(7):e13852. doi:10.1111/acel.13852
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    1. Baron-Stefaniak J, Götz V, Allhutter A, et al. Patients undergoing orthotopic liver transplantation require lower concentrations of the volatile anesthetic sevoflurane. Anesth Analg. 2017;125(3):783-789. doi:10.1213/ANE.0000000000002250

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