Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2024 May 1;209(9):1054-1056.
doi: 10.1164/rccm.202312-2255ED.

Looking Beyond the Lower Airways for Microbes Affecting Pulmonary Fibrosis

Affiliations
Editorial

Looking Beyond the Lower Airways for Microbes Affecting Pulmonary Fibrosis

Fares Darawshy et al. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
The respiratory microbiome in idiopathic pulmonary fibrosis (IPF): what we know and do not know. Current knowledge on the relationship between the airway microbiome and IPF is displayed on the left: increased α diversity and decreased abundance of Streptococcus mitis in the oropharynx are associated with higher mortality risk from IPF, whereas, in the lung, higher bacterial burden and Staphylococcus, Streptococcus, and Haemophilus abundance increase the risk for mortality. What we do not know, which should be the focus of future investigations, is displayed on the right.

Comment on

References

    1. Invernizzi R, Barnett J, Rawal B, Nair A, Ghai P, Kingston S, et al. Bacterial burden in the lower airways predicts disease progression in idiopathic pulmonary fibrosis and is independent of radiological disease extent. Eur Respir J . 2020;55:1901519. - PMC - PubMed
    1. Molyneaux PL, Cox MJ, Willis-Owen SA, Mallia P, Russell KE, Russell AM, et al. The role of bacteria in the pathogenesis and progression of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med . 2014;190:906–913. - PMC - PubMed
    1. Invernizzi R, Wu BG, Barnett J, Ghai P, Kingston S, Hewitt RJ, et al. The respiratory microbiome in chronic hypersensitivity pneumonitis is distinct from that of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med . 2021;203:339–347. - PMC - PubMed
    1. O’Dwyer DN, Ashley SL, Gurczynski SJ, Xia M, Wilke C, Falkowski NR, et al. Lung microbiota contribute to pulmonary inflammation and disease progression in pulmonary fibrosis. Am J Respir Crit Care Med . 2019;199:1127–1138. - PMC - PubMed
    1. Martinez FJ, Yow E, Flaherty KR, Snyder LD, Durheim MT, Wisniewski SR, et al. CleanUP-IPF Investigators of the Pulmonary Trials Cooperative Effect of antimicrobial therapy on respiratory hospitalization or death in adults with idiopathic pulmonary fibrosis: the CleanUP-IPF randomized clinical trial. JAMA . 2021;325:1841–1851. - PMC - PubMed