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Comparative Study
. 1987 Feb 25;15(4):1353-61.
doi: 10.1093/nar/15.4.1353.

Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates

D R Cavener
Free PMC article
Comparative Study

Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates

D R Cavener. Nucleic Acids Res. .
Free PMC article

Abstract

The previously presented consensus sequence for eukaryotic translation initiation sites by Kozak was derived substantially from vertebrate mRNA sequences. Drosophila nuclear genes exhibit a significantly different translation start consensus sequence. These differences probably do not represent mechanistic differences in translation initiation inasmuch as both taxa exhibit identical preferences and restrictions at the crucial -3 position. Using more conservative criteria for the assignment of consensus the following consensus sequences were derived: vertebrate--CANCAUG and Drosophila--CAAAACAUG.

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