Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2023 Dec 13;15(1):6-8.
doi: 10.1021/acsmedchemlett.3c00520. eCollection 2024 Jan 11.

Positive Allosteric Modulators of alpha7 Nicotinic Acetylcholine Receptor for the Treatment of Several Central Nervous System Diseases

Ahmed F Abdel-Magid  1
Affiliations
Editorial

Positive Allosteric Modulators of alpha7 Nicotinic Acetylcholine Receptor for the Treatment of Several Central Nervous System Diseases

Ahmed F Abdel-Magid. ACS Med Chem Lett. .

Abstract

The invention in this patent application relates to spirocyclopropane-2-carboxamide derivatives represented generally by formula 1. These compounds are positive allosteric modulators of α7 nAChR and may be useful in preventing, treating, or ameliorating central nervous system diseases and disorders such as cognitive impairments in Alzheimer's disease, Parkinson's disease, schizophrenia, and L-DOPA-induced dyskinesia as well as inflammation and cough.

PubMed Disclaimer

Conflict of interest statement

The author declares no competing financial interest.

References

    1. Liu H.; Zhang X.; Shi P.; Yuan J.; Jia Q.; Pi C.; Chen T.; Xiong L.; Chen J.; Tang J.; et al. α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect. J. Neuroinflammation 2023, 20, 84. 10.1186/s12974-023-02768-z. - DOI - PMC - PubMed
    1. Burns L. H.; Pei Z.; Wang H.-Y. Targeting α7 nicotinic acetylcholine receptors and their protein interactions in Alzheimer’s disease drug development. Drug Dev. Res. 2023, 84 (6), 1085–1095. 10.1002/ddr.22085. - DOI - PubMed
    1. Sanders V. R.; Millar N. S. Potentiation and allosteric agonist activation of alpha 7 nicotinic acetylcholine receptors: binding sites and hypotheses. Pharmacol. Res. 2023, 191, 106759. 10.1016/j.phrs.2023.106759. - DOI - PubMed
    1. Manetti D.; Dei S.; Arias H. R.; Braconi L.; Gabellini A.; Teodori E.; Romanelli M. N. Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators. Molecules 2023, 28 (3), 1270. 10.3390/molecules28031270. - DOI - PMC - PubMed
    1. Yang T.; Xiao T.; Sun Q.; Wang K. The current agonists and positive allosteric modulators of α7 nAChR for CNS indications in clinical trials. Acta Pharm. Sin. B 2017, 7 (6), 611–622. 10.1016/j.apsb.2017.09.001. - DOI - PMC - PubMed

Publication types

LinkOut - more resources