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. 2023 Dec 26;15(1):4-5.
doi: 10.1021/acsmedchemlett.3c00504. eCollection 2024 Jan 11.

TRIM for Tissue Specificity

Marcus D Hartmann  1   2
Affiliations

TRIM for Tissue Specificity

Marcus D Hartmann. ACS Med Chem Lett. .

Abstract

Tissue-specific manipulation of proteins is a long-standing objective in the field of targeted protein degradation, but still a distant prospect. Currently, the most successfully employed E3 ubiquitin ligases belong to the most ubiquitously expressed representatives. Unlocking of the TRIM58 ligase might represent a promising step toward tissue-specific PROTACs and molecular glue degraders.

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Conflict of interest statement

The author declares no competing financial interest.

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