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Editorial
. 2023 Dec 13;15(1):9-11.
doi: 10.1021/acsmedchemlett.3c00521. eCollection 2024 Jan 11.

Inhibitors of Son of Sevenless Isoform 1 (SOS1) as a Potential Treatment for RAS Mutant Cancers

Ahmed F Abdel-Magid  1
Affiliations
Editorial

Inhibitors of Son of Sevenless Isoform 1 (SOS1) as a Potential Treatment for RAS Mutant Cancers

Ahmed F Abdel-Magid. ACS Med Chem Lett. .

Abstract

The invention in this patent application relates to 1-aminophthalazine derivatives represented generally by formula 1. These compounds are inhibitors of the interaction of the catalytic site of SOS1 with RAS-family proteins which are involved in controlling cell proliferation. They may potentially be used as a treatment for RAS mutant cancers such as pancreatic, lung, and colorectal cancers, cholangiocarcinoma, multiple myeloma, melanoma, and thyroid cancer.

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Conflict of interest statement

The author declares no competing financial interest.

References

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