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Review
. 2024 Jan 12:17:227-240.
doi: 10.2147/JPR.S442298. eCollection 2024.

Association Between Epidural Labor Analgesia and Autism Spectrum Disorder in Offspring: A Systematic Review and Meta-Analysis

Xinyue Hu  1   2   3 , Beibei Wang  1   2   3 , Jing Chen  1   2   3 , Dong Han  1   2   3 , Jing Wu  1   2   3
Affiliations
Review

Association Between Epidural Labor Analgesia and Autism Spectrum Disorder in Offspring: A Systematic Review and Meta-Analysis

Xinyue Hu et al. J Pain Res. .

Abstract

Purpose: Many studies have focused on the association between Autism spectrum disorder (ASD) and epidural labor analgesia (ELA), which is the most effective way to manage labor pain. The purpose of this meta-analysis was to summarize the current state of the association between ELA and ASD.

Methods: A search of the literature yielded 201 relevant studies, of which 7 cohort studies met our inclusion criteria. Two independent reviewers screened the inclusion results, extracted data, and assessed the risk of bias and quality of evidence.

Results: Compared to parturient who did not receive ELA, parturient who received ELA had a slightly increased risk of ASD (adjusted hazard ratio [aHR], 1.12; 95% confidence interval [CI], 1.06-1.17; I2, 69%; P < 0.001; seven studies). After excluding one literature (aHR, 1.09; 95% CI, 1.06-1.12; I2, 4%; P < 0.001; six studies). The sensitivity analyses had consistent outcomes with the main analyses involving siblings (aHR 1.11; 95% CI 1.03-1.19), cesarean section and instrumental deliveries (aHR 1.07; 95% CI 1.03-1.10), non-overlapping populations (aHR 1.09; 95% CI 1.05-1.12), full-term birth populations (aHR 1.10; 95% CI 1.06-1.14), and studies assessed to have moderate risk of bias (aHR 1.09; 95% CI 1.02-1.16).

Conclusion: This meta-analysis revealed a modest positive association between ELA and ASD, acknowledging a slight potential risk. However, it is important to note that this risk cannot be completely dismissed due to the possibility of bias and this association is based on low-quality evidence. Future studies are required to assess and mitigate different confounding biases and investigate the time-dose-response relationship.

Keywords: Autism spectrum disorder; ELA; epidural analgesia; epidural labor analgesia; meta-analysis; neuraxial labor analgesia; pregnancy.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
PRISMA flowchart.
Figure 2
Figure 2
(A) Risk of bias assessment of each individual study. (B) Risk of bias assessment of included studies summary.
Figure 3
Figure 3
The GRADE quality of evidence for the primary outcomes.
Figure 4
Figure 4
Continued.
Figure 4
Figure 4
(A) All forest plots for this analysis. (B) All forest plots for this analysis.
Figure 5
Figure 5
The funnel plot.
See this image and copyright information in PMC

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