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. 2024 Mar 26;8(6):1439-1443.
doi: 10.1182/bloodadvances.2023011327.

Venetoclax-rituximab is active in patients with BTKi-exposed CLL, but durable treatment-free remissions are uncommon

Affiliations

Venetoclax-rituximab is active in patients with BTKi-exposed CLL, but durable treatment-free remissions are uncommon

Thomas E Lew et al. Blood Adv. .
No abstract available

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Conflict of interest statement

Conflict-of-interest disclosure: A.W.R., M.A.A., T.E.L., and V.S.L. are employees of the Walter and Eliza Hall Institute of Medical Research, which receives milestone and royalty payments related to VEN. A.W.R., M.A.A., and T.E.L. are recipients of a share in royalty payments paid to the Walter and Eliza Hall Institute of Medical Research. T.E.L. has received honoraria from AbbVie. R.B. has received sponsorship from AbbVie. S.M.H. has received honoraria from AstraZeneca, Janssen, and Gilead, and nonfinancial assistance from AbbVie. P.M. has served on advisory boards for, and received honoraria or speaker fees from, AbbVie, BeiGene, Janssen, AstraZeneca, Astellas, Otsuka, Menarini, and Jazz. S.P.M. has acted as a consultant/advisor for AbbVie, AstraZeneca, BeiGene, Janssen, Gilead, and Roche. A.W. is an advisory board member for AbbVie and AstraZeneca, and has received honoraria from AbbVie, Roche, AstraZeneca, Novartis, and BeiGene. C.S.T. has received honoraria and research funding from AbbVie and Janssen, and received honoraria from BeiGene. A.W.R. received research funding from AbbVie, Genentech, Servier, Janssen, and BeiGene. J.F.S. receives research funding from AbbVie, Genentech, Celgene, and Janssen, and is an advisory board member for, and has received honoraria from, AbbVie, Acerta, Celgene, Genentech, Janssen, Roche, Sunesis, and Takeda. M.A.A. has received honoraria from AbbVie, Janssen, AstraZeneca, Novartis, Takeda, Kite, and CSL Behring. P.A.T. has received honoraria from AbbVie, Adaptive Biotechnologies, AstraZeneca, BeiGene, Genentech, Janssen, Lilly, Merck, and Pharmacyclics. The remaining authors declare no competing financial interests.

Figures

Figure 1.
Figure 1.
Outcomes after VEN-based regimens for patients with cBTKi-exposed CLL. (A) PFS and OS for patients who received VEN-R; (B) PFS and OS for patients who received VEN monotherapy; and (C) PFS, stratified by TP53 status for patients receiving VEN-based therapy.

References

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    1. Fischer K, Al-Sawaf O, Bahlo J, et al. Venetoclax and obinutuzumab in patients with CLL and coexisting conditions. N Engl J Med. 2019;380(23):2225–2236. - PubMed
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    1. Lew TE, Seymour JF. Clinical experiences with venetoclax and other pro-apoptotic agents in lymphoid malignancies: lessons from monotherapy and chemotherapy combination. J Hematol Oncol. 2022;15(1):75. - PMC - PubMed

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