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Review
. 2024 Jun;17(3):624-637.
doi: 10.1007/s12265-024-10480-3. Epub 2024 Jan 17.

The Gut Microbiome Affects Atherosclerosis by Regulating Reverse Cholesterol Transport

Yangyang Jiang #  1   2   3 , Shuchao Pang #  4   5 , Xiaoyu Liu  1   2   3 , Lixin Wang  1   2   3 , Yi Liu  6   7
Affiliations
Review

The Gut Microbiome Affects Atherosclerosis by Regulating Reverse Cholesterol Transport

Yangyang Jiang et al. J Cardiovasc Transl Res. 2024 Jun.

Abstract

The human system's secret organ, the gut microbiome, has received considerable attention. Emerging research has yielded substantial scientific evidence indicating that changes in gut microbial composition and microbial metabolites may contribute to the development of atherosclerotic cardiovascular disease. The burden of cardiovascular disease on healthcare systems is exacerbated by atherosclerotic cardiovascular disease, which continues to be the leading cause of mortality globally. Reverse cholesterol transport is a powerful protective mechanism that effectively prevents excessive accumulation of cholesterol for atherosclerotic cardiovascular disease. It has been revealed how the gut microbiota modulates reverse cholesterol transport in patients with atherosclerotic risk. In this review, we highlight the complex interactions between microbes, their metabolites, and their potential impacts in reverse cholesterol transport. We also explore the feasibility of modulating gut microbes and metabolites to facilitate reverse cholesterol transport as a novel therapy for atherosclerosis.

Keywords: Atherosclerosis; Cholesterol; Gut microbiome; Reverse cholesterol transport.

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