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. 2024 Jul;45(7):3153-3161.
doi: 10.1007/s10072-024-07304-2. Epub 2024 Jan 17.

Validation of the Italian version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) in an Italian Parkinson's disease cohort

Gianpaolo Maggi  1   2 , Carmine Vitale  3   4 , Chiara Giacobbe  1 , Angelo Barone  1 , Clara Mastromarino  1 , Federica Iannotta  5 , Marianna Amboni  4   6 , Daniel Weintraub  7 , Gabriella Santangelo  8
Affiliations

Validation of the Italian version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) in an Italian Parkinson's disease cohort

Gianpaolo Maggi et al. Neurol Sci. 2024 Jul.

Abstract

Introduction: Impulse control disorders (ICDs) frequently occur in Parkinson's disease (PD), and an early identification is essential to prevent severe psychosocial consequences. The Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) has been developed to evaluate the severity of ICDs along with a range of impulsive-compulsive behaviors (ICBs) in PD; however, its Italian version has not yet been validated.

Methods: One hundred consecutive outpatients with PD were administered an Italian version of the QUIP-RS and a brief neuropsychological assessment to evaluate global cognitive status and scales to measure depression, apathy and impulsive disorders. We evaluated the internal consistency, convergent and divergent validity, and factorial structure of QUIP-RS. We also explored the possible association between QUIP-RS scores and clinical factors and dopaminergic medication.

Results: Subsyndromal ICDs manifestations were observed in 54% of the patients, and one in four (22%) reported two or more ICDs or related behaviors. The QUIP-RS demonstrated good internal consistency (Cronbach's alpha = 0.806) and construct validity, and its factorial structure reflected different ICDs and ICBs domains. No association emerged between QUIP-RS scores and the clinical aspects of PD and dopaminergic medication.

Conclusion: We provided, for the first time, an Italian translation of the QUIP-RS and demonstrated its feasibility in clinical and research settings. Severity of ICDs was independent of clinical factors and dopaminergic medication, underlining the need to adopt a broader perspective on their etiopathology in PD.

Keywords: Impulse control disorder; Impulsivity; Parkinson’s disease; QUIP; Rating scale; Validation.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Pie charts displaying percentages of the prevalence of impulse control disorder and related behavior (ICDs) in Parkinson’s disease (PD+ICD) according to the QUIP-RS. In detail, on the right, the frequencies of specific ICDs and related behaviors within PD+ICD single and multiple domains. Note that percentages of specific ICDs and related behaviors within PD+ICD multiple domains chart exceed 100% due to comorbidity
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