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Review
. 2024 Jan 18;390(3):242-253.
doi: 10.1056/NEJMra2202762.

Syphilis Complicating Pregnancy and Congenital Syphilis

Irene A Stafford  1 , Kimberly A Workowski  1 , Laura H Bachmann  1
Affiliations
Review

Syphilis Complicating Pregnancy and Congenital Syphilis

Irene A Stafford et al. N Engl J Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.. Clinical Manifestations of Primary and Secondary Syphilis.
Panel A shows a chancre in primary syphilis. Panels B and C show alopecia and condyloma lata, respectively, in secondary syphilis.
Figure 2.
Figure 2.. Oral and Cutaneous Manifestations of Secondary Syphilis.
Panel A shows oral condyloma lata, Panel B shows a mucosal patch on the tongue, and Panels C, D, and E show plantar, palmar, and truncal rashes, respectively.
Figure 3.
Figure 3.. Sonographic, Radiographic, and Cutaneous Manifestations of Congenital Syphilis.
Panel A shows ultrasonographic evidence of placentomegaly (>95% for gestational age). Panels B and C show radial and ulnar periostitis and maculopapular rash, respectively, in early congenital syphilis.
Figure 4.
Figure 4.. Clinical Signs of Early Congenital Syphilis.
Clinical findings of early congenital syphilis include neurosyphilis, syphilitic rhinitis, anemia, hepatobiliary dysfunction, cutaneous lesions or rash, and osteochondritis or periostitis. Shown are clinical signs in children under 2 years of age.
Figure 5.
Figure 5.. Clinical Manifestations of Congenital Syphilis.
Panel A shows neonatal plantar rash, Panel B shows snuffles, and Panel C shows erosive lesions involving the buttocks.
See this image and copyright information in PMC

Comment in

References

    1. Obladen M Curse on two generations: a history of congenital syphilis. Neonatology 2013; 103: 274–80. - PubMed
    1. Center for Disease Control and Prevention. Sexually transmitted disease surveillance 2021. (https://www.cdc.gov/std/statistics/2021/default.htm).
    1. Martin EG, Ansari B, Rosenberg ES, et al. Variation in patterns of racial and ethnic disparities in primary and secondary syphilis diagnosis rates among heterosexually active women by region and age group in the United States. Sex Transm Dis 2022; 49: 330–7. - PMC - PubMed
    1. Coselli J, Rac M, Wilson D, Wang C, Sibai BM, Stafford IA. Risk factors associated with gaps in post-treatment surveillance for perinatal syphilis. Am J Obstet Gynecol 2022; 226: Suppl: S673–S675.
    1. Stafford IA, Coselli JO, Wilson DF, Wang CY, Sibai BM. Comparison of sexually transmitted infections and adverse perinatal outcomes in underserved pregnant patients before vs during the COVID-19 pandemic in Texas. JAMA Netw Open 2022; 5(2): e220568. - PMC - PubMed

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