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Abstract

During May 2022-April 2023, dengue virus serotype 3 was identified among 601 travel-associated and 61 locally acquired dengue cases in Florida, USA. All 203 sequenced genomes belonged to the same genotype III lineage and revealed potential transmission chains in which most locally acquired cases occurred shortly after introduction, with little sustained transmission.

Keywords: DENV; DENV-3; Florida; United States; dengue virus; phylogenetics; transmission reconstruction; vector-borne infections; viruses; whole-genome sequencing.

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Figures

Figure 1
Figure 1
DENV serotype distribution and DENV-3 case distribution by week of symptom onset, county of reporting, and origin of travel, Florida, USA, May 1, 2022–April 30, 2023. A) Number of dengue cases by each virus serotype. Cases with an unknown dengue virus type (asterisk) only had a positive serologic test or multiple serotypes identified. B) Epidemic curve of reported cases of DENV-3, showing 601 travel-associated cases and 61 locally acquired cases. C) Heat map indicating number of DENV-3 cases by county and by travel history. Other countries were Bangladesh, Colombia, Guyana, India, Jamaica, Mexico, Pakistan, and Sri Lanka. The names of counties reporting >3 DENV-3 cases are shown and sorted by the total number of cases reported. DENV, dengue virus; DENV-3, DENV serotype 3.
Figure 2
Figure 2
Evolutionary analysis of dengue virus serotype 3 sampled in Florida, USA, May 1, 2022–April 30, 2023. Maximum-likelihood phylogenetic tree was generated from a subset of 203 complete genomes from Florida (34 local cases, 168 cases in persons with recent travel history to Cuba, and 1 traveler case from Guyana) and 146 complete genomes publicly available (1985–2022) from GenBank representing genotype III, American lineage II. A subset of the sequences was used because of the low diversity in the population sample, which was limiting the phylogenetic signal and hampering the statistical analyses that supported the tree accuracy and certainty in major nodes. Sampling locations are coded by shape and color. Scale bar represents nucleotide substitutions per site.
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