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Comment
. 2023 Oct;3(4):43.
doi: 10.20517/jca.2023.37. Epub 2023 Oct 25.

Fibroblasts, myofibroblasts and cardiac arrhythmias

Nikolaos G Frangogiannis  1
Affiliations
Comment

Fibroblasts, myofibroblasts and cardiac arrhythmias

Nikolaos G Frangogiannis. J Cardiovasc Aging. 2023 Oct.
No abstract available

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Conflict of interest statement

Conflicts of interest The author declared that there are no conflicts of interest.

Figures

Figure 1.
Figure 1.
Fibroblast-driven arrhythmogenesis in myocardial infarction. A recently published study by Wang et al. documented for the first time that fibroblasts in infarcted hearts can couple with cardiomyocytes and trigger arrhythmias[8]. Thus, fibrosis can promote arrhythmogenesis not only through the conduction-blocking effects of the extracellular matrix deposited between cardiomyocytes, but also through direct fibroblast-mediated cardiomyocyte excitation. Coupling may involve both gap junctional and ephaptic coupling. The study also raises several intriguing questions for further investigation.
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References

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