Biological ageing and the human genome

Abstract

Age is a crucial prognostic factor across clinical specialities with significant implications for medical practice. Increasingly, "biological age" is being used as a more relevant age marker in a clinical context and is heavily integrated into the medical use of AI. This review describes the current knowledge about molecular biological and genetic aging-related changes associated with the genome and epigenome, used for biological age determination. It explores the potential causes of these changes and provides an update on treatment status and "rejuvenation" of these genome-related factors.