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. 2024 Mar;27(1):129-135.
doi: 10.1007/s40477-023-00844-x. Epub 2024 Jan 18.

Problems with gestational age estimation by last menstrual period and ultrasound among late antenatal care attendant women in a low-resource setting in Africa, Sudan

Amjad Alyahyawi  1   2 , Gamal K Adam  3 , Nadiah AlHabardi  4 , Ishag Adam  5
Affiliations

Problems with gestational age estimation by last menstrual period and ultrasound among late antenatal care attendant women in a low-resource setting in Africa, Sudan

Amjad Alyahyawi et al. J Ultrasound. 2024 Mar.

Abstract

Introduction: Accurate estimation of gestational age is essential to interpret and manage several maternal and perinatal indicators. Last menstrual period (LMP) and ultrasound are the two most common methods used for estimating gestational age. There are few published studies comparing the use of LMP and ultrasound in Sub-Saharan Africa to estimate gestational age and no studies on this topic in Sudan.

Material and methods: A cross-sectional study was conducted in Gadarif Maternity Hospital in Sudan during November through December 2022. Sociodemographic information was collected, and the date of the first day of each participant's LMP was recorded. Ultrasound examinations were performed (measuring crown-rump length in early pregnancy and biparietal diameter and femur length in late pregnancy) using a 3.5-MHz electronic convex sector probe. Bland-Altman analysis was performed.

Results: Four-hundred seventy-six pregnant women were enrolled. The median (interquartile range [IQR]) age and gravidity was 24.0 (20.0‒29.0) years and 2 (1‒4), respectively. There was a strong positive correlation between gestational age determined by LMP and ultrasound (r = 0.921, P < 0.001). The mean gestational age estimate according to LMP was higher than that determined by ultrasound, with a difference, on average, of 0.01 week (95% confidence interval [CI]: - 0.05, 0.07). Bland-Altman analysis showed the limits of agreement varied from - 1.36 to 1.38 weeks. A linear regression analysis showed proportional bias. The coefficient of difference of the mean was equal to 0.26 (95% CI: 0.01, 0.03, P < 0.001).

Conclusion: Based on our results, there was a bias in LMP-based gestational age estimates when compared with the reproducible method (ultrasound).

Keywords: Gestational age; Last menstrual period; Pregnancy; Ultrasound.

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Conflict of interest statement

The authors have no relevant financial or non-financial interests to disclose.

Figures

Fig. 1
Fig. 1
Flow diagram for eligibility of pregnant women in eastern Sudan in accessing gestational age, 2022
Fig. 2
Fig. 2
Distribution of gestational age estimated by last menstrual period and ultrasound among pregnant women in eastern Sudan, 2022
Fig. 3
Fig. 3
Bland–Altman analysis of gestational age estimated by last menstrual period and ultrasound among pregnant women in eastern Sudan, 2022
See this image and copyright information in PMC

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