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Comment
. 2024 Apr 15;209(8):1033-1034.
doi: 10.1164/rccm.202311-2189LE.

Identification of Alpha-1 Antitrypsin-Deficient Subjects with Normal Spirometry Who May Benefit from Alpha-1 Antitrypsin Replacement

Edward D Chan  1
Affiliations
Comment

Identification of Alpha-1 Antitrypsin-Deficient Subjects with Normal Spirometry Who May Benefit from Alpha-1 Antitrypsin Replacement

Edward D Chan. Am J Respir Crit Care Med. .
No abstract available

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References

    1. Fraughen DD, Ghosh AJ, Hobbs BD, Funk GC, Meischl T, Clarenbach CF, et al. Augmentation therapy for severe alpha-1 antitrypsin deficiency improves survival and is decoupled from spirometric decline—a multinational registry analysis. Am J Respir Crit Care Med . 2023;208:964–974. - PMC - PubMed
    1. Parr DG, Guest PG, Reynolds JH, Dowson LJ, Stockley RA. Prevalence and impact of bronchiectasis in alpha1-antitrypsin deficiency. Am J Respir Crit Care Med . 2007;176:1215–1221. - PubMed
    1. Jonigk D, Al-Omari M, Maegel L, Müller M, Izykowski N, Hong J, et al. Anti-inflammatory and immunomodulatory properties of α1-antitrypsin without inhibition of elastase. Proc Natl Acad Sci USA . 2013;110:15007–15012. - PMC - PubMed
    1. McElvaney OJ, McEvoy NL, McElvaney OF, Carroll TP, Murphy MP, Dunlea DM, et al. Characterization of the inflammatory response to severe COVID-19 illness. Am J Respir Crit Care Med . 2020;202:812–821. - PMC - PubMed

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