Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Mar-Apr;90(2):101380.
doi: 10.1016/j.bjorl.2023.101380. Epub 2023 Dec 19.

Evaluation of inner ear damage by mastoid drilling with measurement of serum prestin (SLC26A5) levels

Ayca Baskadem Yilmazer  1 , Onur Tanrısever  2 , Maide Hacer Alagoz  3 , Rasim Yilmazer  4 , Ayse Enise Goker  2 , Belgin Tutar  2 , Yavuz Uyar  2
Affiliations

Evaluation of inner ear damage by mastoid drilling with measurement of serum prestin (SLC26A5) levels

Ayca Baskadem Yilmazer et al. Braz J Otorhinolaryngol. 2024 Mar-Apr.

Abstract

Objective: The objective of this study is to demonstrate any inner ear injury caused by drilling in mastoid surgery with prestin, outer hair cell motor protein specific to the cochlea.

Methods: The patients with chronic otitis media requiring mastoidectomy (n = 21) and myringoplasty (n = 21) were included. Serum prestin level obtained from blood samples was measured before surgery and on postoperative days 0, 3, and 7 using Human Prestin (SLC26A5) ELISA Kit. All patients underwent the Pure Tone Audiometry (PTA) test before surgery and on the postoperative 7th day. The drilling time was also recorded for all patients who underwent mastoidectomy.

Results: In both mastoidectomy and myringoplasty groups, the postoperative serum prestin levels increased on days 0 and 7 (pday-0 = 0.002, pday-7 = 0.001 and pday-0 = 0.005, pday-7 = 0.001, respectively). There was no significant difference in the serum prestin levels between the two groups, postoperatively. The PTA thresholds at day 7 did not change in either group. A significant decline at 2000 Hz of bone conduction hearing threshold in both groups and a decline at 4000 Hz in the myringoplasty group were found. There was no correlation between the drilling time and the increase of prestin levels in the postoperative day 0, 3, and 7.

Conclusion: Our results showed that mastoid drilling is not related to a significant inner ear injury. Although the myringoplasty group was not exposed to drill trauma, there was a similar increase in serum prestin levels as the mastoidectomy group. Also, a significant decline at 2000 Hz of bone conduction hearing threshold in both groups and a decline at 4000 Hz in the myringoplasty group were found. These findings suggest that suction and ossicular manipulation trauma can lead to an increase in serum prestin levels and postoperative temporary or permanent SNHL at 2000 and 4000 Hz.

Level of evidence: Level-4.

Keywords: Drill; Inner ear; Mastoidectomy; Prestin; SLC26A5.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Comparison of serum prestin levels of two groups at different days.
Figure 2
Figure 2
Comparison of the bone conduction hearing thresholds of both groups at pre and postoperative periods.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Palva T., Kärjä J., Palva A. High-tone sensorineural losses following chronic ear surgery. Arch Otolaryngol. 1976;102:137–139. - PubMed
    1. Tos M., Lau T., Plate S. Sensorineural hearing loss following chronic ear surgery. Ann Otol Rhinol Laryngol. 1984;93:403–409. - PubMed
    1. Suits G.W., Brummett R.E., Nunley J. Effect of otologic drill noise on ABR thresholds in a guinea pig model. Otolaryngol Head Neck Surg. 1993;109:660–667. - PubMed
    1. Urquhart A.C., McIntosh W.A., Bodenstein N.P. Drill-generated sensorineural hearing loss following mastoid surgery. Laryngoscope. 1992;102:689–692. - PubMed
    1. Banakis Hartl R.M., Mattingly J.K., Greene N.T., Farrell N.F., Gubbels S.P., Tollin D.J. Drill-induced cochlear injury during otologic surgery: intracochlear pressure evidence of acoustic trauma. Otol Neurotol. 2017;38:938–947. - PMC - PubMed

Substances