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Review
. 2023 Nov:251:154912.
doi: 10.1016/j.prp.2023.154912. Epub 2023 Oct 26.

Circular RNAs and inflammation: Epigenetic regulators with diagnostic role

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Free article
Review

Circular RNAs and inflammation: Epigenetic regulators with diagnostic role

Soudeh Ghafouri-Fard et al. Pathol Res Pract. 2023 Nov.
Free article

Abstract

Circular RNAs (circRNAs) are a group of transcripts generally known to be non-coding transcripts, but occasionally producing short peptides. Circ_Ttc3/miR-148a, circ_TLK1/miR-106a-5p, circ_VMA21/miR-9-3p, circ_0068,888/miR-21-5p, circ_VMA21/miR-199a-5p, circ_AFF2/miR-375, circ_0008360/miR-135b-5p and circ-FBXW7/miR-216a-3p are examples of circRNA/miRNA pairs that contribute in the pathogenesis of immune-related conditions. CircRNAs have been found to regulate function of immune system and participate in the pathophysiology of immune-related disorders. In the current study, we searched PubMed and Google Scholar databases until July 2022 with the key words "circRNA" OR "circular RNA" AND "inflammation". Then, we assessed the abstract of retrieved articles to include original articles that assessed contribution of circRNAs in the pathoetiology of inflammation and related disorders. Finally, we went through the main texts of the articles and tabulated the available information. Therefore, the current study summarizes the role of circRNAs in the pathoetiology of sepsis, atherosclerosis, rheumatoid arthritis and osteoarthritis, immune-related cardiovascular, pulmonary, gastrointestinal and nervous system disorders.

Keywords: Biomarker; CircRNA; Diagnostic; Expression; Inflammation.

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Conflict of interest statement

Declaration of Competing Interest The authors declare they have no conflict of interest.

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