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. 2024 Jan 18;14(1):1663.
doi: 10.1038/s41598-024-52175-4.

Investigating the causal relationship between physical activity and incident knee osteoarthritis: a two-sample Mendelian randomization study

Liufang Huang  1 , Yuling Zhang  1 , Qian Li  2
Affiliations

Investigating the causal relationship between physical activity and incident knee osteoarthritis: a two-sample Mendelian randomization study

Liufang Huang et al. Sci Rep. .

Abstract

There is evidence that physical activity (PA) has a long-term positive impact on disease. Whether PA is a risk factor for knee osteoarthritis (OA) is still controversial. The purpose of this study was to explore whether there is a causal relationship between PA and knee OA. We extracted PA and knee OA data from genome-wide association study (GWAS) databases. We used single-nucleotide polymorphisms (SNPs) as instrumental variables. We performed MR analysis by random-effects inverse-variance weighting (IVW), MR‒Egger, weighted median, simple mode, and weighted mode methods. We evaluated the stability and reliability of the results through sensitivity analysis. There was no significant association between PA and knee OA (p > 0.05). We did not detect any pleiotropy (MR‒Egger intercept test et al.: p > 0.05). The sensitivity analysis confirmed our results (p > 0.05). There is no causal relationship between PA and knee OA.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
The results of MR‒Egger regression. MR Mendelian randomization.
Figure 2
Figure 2
The results of funnel plot. MR Mendelian randomization.
Figure 3
Figure 3
MR leave-one-out sensitivity analysis. MR Mendelian randomization.
See this image and copyright information in PMC

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