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. 2024 Jan 18;24(1):59.
doi: 10.1186/s12872-024-03718-0.

The investigation of thrombocytopenia after transcatheter occlusion of patent ductus arteriosus

Jipei Wang  1 , Xiaoming Wang  2 , Xuefei Xu  2 , Limin Xie  2 , Pengwei Yang  2
Affiliations

The investigation of thrombocytopenia after transcatheter occlusion of patent ductus arteriosus

Jipei Wang et al. BMC Cardiovasc Disord. .

Abstract

Objective: To investigate the risk factors for thrombocytopenia after transcatheter occlusion operation of patent ductus arteriosus (PDA).

Method: Retrospective analyses were conducted using clinical data from 106 patients with PDA who underwent transcatheter closure operations at Henan Provincial Chest Hospital, Zhengzhou University, from January 2018 to June 2022. The study compared the changes in platelet counts before and after the operation, and investigated the risk factors for thrombocytopenia following PDA closure in different groups and layers.

Results: The platelet count of patients with PDA significantly decreased after undergoing transcatheter PDA occlusion. Logistic regression analysis revealed that factors such as PDA diameter, occluder diameter, pressure difference on the two sides of the occluder, and residual shunt were associated with an increased risk of thrombocytopenia following PDA occlusion. Specifically, the size of the occluder and the pressure difference between the two sides of the occluder were found to have a negative correlation with the postoperative platelet count. Further subgroup analysis demonstrated that the incidence of total thrombocytopenia was significantly higher in the large PDA group compared to the small-medium PDA groups.

Conclusion: Our findings suggest that occluder diameter, the pressure difference between the two sides of the occluder, and the residual shunt are major risk factors correlated with the incidence of postoperative thrombocytopenia. However, a multicenter and long-term prospective study is required to further evaluate the prognosis of PDA patients with thrombocytopenia after transcatheter occlusion.

Keywords: Complication; Patent ductus arteriosus; Thrombocytopenia; Transcatheter occlusion.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Relationship between platelet count, PDA diameter and pressure difference on both sides of occluder
Fig. 2
Fig. 2
Predictive value of PDA defect diameter and occluder diameter for thrombocytopenia in PDA patients after occlusion surgery
See this image and copyright information in PMC

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