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. 2024 Dec;13(1):2302843.
doi: 10.1080/22221751.2024.2302843. Epub 2024 Jan 18.

Candida auris-associated hospitalizations and outbreaks, China, 2018-2023

Jian Bing  1   2 , Han Du  2 , Penghao Guo  3 , Tianren Hu  2 , Meng Xiao  4 , Sha Lu  5 , Clarissa J Nobile  6   7 , Haiqing Chu  1   8 , Guanghua Huang  2
Affiliations

Candida auris-associated hospitalizations and outbreaks, China, 2018-2023

Jian Bing et al. Emerg Microbes Infect. 2024 Dec.

Abstract

The emerging human fungal pathogen Candida auris has become a serious threat to public health. This pathogen has spread to 10 provinces in China as of December 2023. Here we describe 312 C. auris-associated hospitalizations and 4 outbreaks in healthcare settings in China from 2018 to 2023. Three genetic clades of C. auris have been identified during this period. Molecular epidemiological analyses indicate that C. auris has been introduced and local transmission has occurred in multiple instances in China. Most C. auris isolated from China (98.7%) exhibited resistance to fluconazole, while only a small subset of strains were resistant to amphotericin B (4.2%) and caspofungin (2.2%).

Keywords: Candida auris; China; emerging fungal pathogen; molecular epidemiology; outbreaks.

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Conflict of interest statement

Clarissa J. Nobile is a cofounder of BioSynesis, Inc., a company developing diagnostics and therapeutics for biofilm infections.

Figures

Figure 1.
Figure 1.
Maximum-likelihood phylogeny analysis of representative C. auris strains isolated from different hospitals in China based on genomic sequences. Phylogenetic tree of 34 representative C. auris strains from China were constructed based on whole genome SNPs and 1000 bootstrap replicates. Data of C. auris clade IV and clade V strains were retrieved from the NCBI SRA database. The hospitals (H1–H18) and provinces from which the C. auris strains were isolated are also shown. Strains of clade I, II, and III isolated in China are indicated in red, pink, and blue, respectively.
See this image and copyright information in PMC

References

    1. Satoh K, Makimura K, Hasumi Y, et al. . Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital. Microbiol Immunol. 2009 Jan;53(1):41–44. doi:10.1111/j.1348-0421.2008.00083.x - DOI - PubMed
    1. Du H, Bing J, Hu T, et al. . Candida auris: epidemiology, biology, antifungal resistance, and virulence. PLoS Pathog. 2020 Oct;16(10):e1008921. doi:10.1371/journal.ppat.1008921 - DOI - PMC - PubMed
    1. Chowdhary A, Jain K, Chauhan N.. Candida auris genetics and emergence. Annu Rev Microbiol. 2023 Sep 15; 77:583-602. doi:10.1146/annurev-micro-032521-015858 - DOI - PubMed
    1. Chen Y, Zhao J, Han L, et al. . Emergency of fungemia cases caused by fluconazole-resistant Candida auris in Beijing, China. J Infect. 2018 Dec;77(6):561–571. doi:10.1016/j.jinf.2018.09.002 - DOI - PubMed
    1. Tian S, Rong C, Nian H, et al. . First cases and risk factors of super yeast Candida auris infection or colonization from Shenyang, China. Emerg Microbes Infect. 2018 Jul 11;7(1):128. - PMC - PubMed

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