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Review
. 2024 Jan 4:14:1275506.
doi: 10.3389/fphys.2023.1275506. eCollection 2023.

Benefits of topical natural ingredients in epidermal permeability barrier

Dongyun Lei #  1 , Dan Liu #  2 , Junling Zhang  1 , Litao Zhang  1 , Mao-Qiang Man  2   3
Affiliations
Review

Benefits of topical natural ingredients in epidermal permeability barrier

Dongyun Lei et al. Front Physiol. .

Abstract

Because of the crucial role of epidermal permeability barrier in regulation of cutaneous and extracutaneous functions, great efforts have been made to identify and develop the regimens that can improve epidermal permeability barrier function. Studies have demonstrated that oral administration of natural ingredients can improve epidermal permeability barrier in various skin conditions, including inflammatory dermatoses and UV-irradiation. Moreover, topical applications of some natural ingredients can also accelerate the repair of epidermal permeability barrier after acute barrier disruption and lower transepidermal water loss in the intact skin. Natural ingredient-induced improvements in epidermal permeability barrier function can be attributable to upregulation of keratinocyte differentiation, lipid production, antioxidant, hyaluronic acid production, expression of aquaporin 3 and sodium-hydrogen exchanger 1. In this review, we summarize the benefits of topical natural ingredients in epidermal permeability barrier in normal skin with or without acute barrier disruption and the underlying mechanisms.

Keywords: barrier; epidermis; natural ingredients; permeability; topical; transepidermal water loss.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Benefits of topical natural ingredients on epidermal permeability barrier and clinical applications.
See this image and copyright information in PMC

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