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. 2024 Jul 1;20(3):239-246.
doi: 10.4103/jmas.jmas_265_23. Epub 2024 Jan 19.

The use of lidocaine infusion in laparoscopic cholecystectomy: An updated systematic review and meta-analysis

Bakhtawar Awan  1 , Mohamed Elsaigh  1 , Beshoy Effat Elkomos  1 , Azka Sohail  1 , Ahmad Asqalan  2 , Safa Owhida Mousa Baqar  3 , Noha Ahmed Elgendy  4 , Omnia S Saleh  5 , Justyna Malgorzata Szul  1 , Anna San Juan  1 , Mohamed Alasmar  6 , Mohamed Mustafa Marzouk  1   7
Affiliations

The use of lidocaine infusion in laparoscopic cholecystectomy: An updated systematic review and meta-analysis

Bakhtawar Awan et al. J Minim Access Surg. .

Abstract

Being one of the most common abdominal surgical procedures, numerous techniques have been adapted to decrease post-operative pain post cholecystectomy. However, the efficacy of intravenous (IV) lidocaine in managing post operative pain after LC is still controversial, according to many recent studies. This study aims to detect the effectiveness of IV lidocaine compared to other medications in managing post-operative pain. PubMed, Scopes, Web of Science and Cochrane Library were searched for eligible studies from inception to June 2023, and a systematic review and meta-analysis was done. According to eligibility criteria, 14 studies (898 patients) were included in our study. The pooled results of the included studies showed that the pain score after 6, 12 and 24 h after the surgery was significantly lower in those who received IV lidocaine as a painkiller (Visual Analogue Scale [VAS] 6H, mean difference [MD] = -1.20, 95% confidence interval [CI] = -2.20, -0.20, P = 0.02; I2 = 98%, VAS 12H, MD = -0.90, 95% CI = -1.52, -0.29, P = 0.004; I2 = 96% and VAS 24H, MD = -0.86, 95% CI = -1.48, -0.24, P = 0.007; I2 = 92%). In addition, IV lidocaine is associated with a significant decrease in the opioid requirement after the surgery (opioid requirements, MD = -29.53, 95% CI = -55.41, -3.66, P = 0.03; I2 = 98%). However, there was no statistically significant difference in the incidence of nausea and vomiting after the surgery between the two groups (nausea and vomiting, relative risk = 0.91, 95% CI = 0.57, 1.45, P = 0.69; I2 = 50%). Lidocaine infusion in LC is associated with a significant decrease in post operative pain and in opioid requirements after the surgery.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram
Figure 2
Figure 2
Visual Analogue Scale pain score. IV: Intravenous, CI: Confidence interval, VAS: Visual Analogue Scale, SD: Standard deviation
Figure 3
Figure 3
Total opioid requirements. IV: Intravenous, CI: Confidence interval, SD: Standard deviation
Figure 4
Figure 4
Post-operative nausea and vomiting. IV: Intravenous, CI: Confidence interval
See this image and copyright information in PMC

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