Executive Summary: Guidelines on Use of Corticosteroids in Critically Ill Patients With Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia Focused Update 2024

Dipayan Chaudhuri^{1

2}, Andrea M Nei³, Bram Rochwerg^{1

2}, Robert A Balk⁴, Karim Asehnoune⁵, Rhonda S Cadena⁶, Joseph A Carcillo⁷, Ricardo Correa⁸, Katherine Drover⁹, Annette M Esper¹⁰, Hayley B Gershengorn^{11

12}, Naomi E Hammond^{13

14}, Namita Jayaprakash^{15

16}, Kusum Menon¹⁷, Lama Nazer¹⁸, Tyler Pitre^{1

2}, Zaffer A Qasim¹⁹, James A Russell²⁰, Ariel P Santos²¹, Aarti Sarwal²², Joanna Spencer-Segal²³, Nejla Tilouche²⁴, Djillali Annane^{25

26

27}, Stephen M Pastores²⁸

Affiliations

¹ Department of Medicine, McMaster University, Hamilton, ON, Canada.
² Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
³ Department of Pharmacy, Mayo Clinic Hospital-Rochester, Rochester, MN.
⁴ Department of Internal Medicine, Rush University Medical Center, Chicago, IL.
⁵ Department of Anesthesiology, CHU Nantes, Université de Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, France.
⁶ Department of Internal Medicine, Wake Forest School of Medicine, Atrium Health, Carolinas Medical Center, Charlotte, NC.
⁷ Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, PA.
⁸ Department of Endocrinology, Diabetes and Metabolism, Endocrine and Metabolism Institute, Cleveland Clinic, Cleveland, OH.
⁹ McMaster University, Hamilton, ON, Canada.
¹⁰ Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, Atlanta, GA.
¹¹ Division of Pulmonary, Critical Care, and Sleep Medicine, University of Miami Miller School of Medicine, Miami, FL.
¹² Division of Critical Care Medicine, Albert Einstein College of Medicine, Bronx, NY.
¹³ Malcolm Fisher Department of Intensive Care Medicine, Critical Care Program, The George Institute for Global Health, UNSW Sydney, Newtown, NSW, Australia.
¹⁴ Malcolm Fisher Department of Intensive Care, Royal North Shore Hospital, St Leonards, NSW, Australia.
¹⁵ Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI.
¹⁶ Division of Pulmonary and Critical Care Medicine, Henry Ford Hospital, Detroit, MI.
¹⁷ Division of Pediatric Critical Care, Department of Pediatrics, University of Ottawa, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
¹⁸ King Hussein Cancer Center Department of Pharmacy, Amman, Jordan.
¹⁹ Department of Emergency Medicine and Critical Care Medicine, University of Pennsylvania Health System, Philadelphia, PA.
²⁰ Division of Critical Care, Department of Medicine, Centre for Heart Lung Innovation St. Paul's Hospital University of British Columbia, Vancouver, BC, Canada.
²¹ Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, TX.
²² Department of Neurology [Neurocritical Care], Atrium Wake Forest School of Medicine, Winston Salem, NC.
²³ Department of Internal Medicine, Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI.
²⁴ Intensive Care Unit, Service de Réanimation Polyvalente, Hôpital de Gonesse, Grenoble, France.
²⁵ Department of Intensive Care, Raymond Poincaré Hospital, Assistance Publique-Hôpitaux de Paris, Garches, France.
²⁶ School of Medicine Simone Veil, University of Versailles Saint Quentin, University Paris-Saclay, Versaillles, France.
²⁷ IHU Prometheus Fédération Hospitalo-Universitaire SEPSIS, University Paris-Saclay, INSERM, Garches, France.
²⁸ Department of Anesthesiology and Critical Care Medicine, Critical Care Center, Memorial Sloan Kettering Cancer Center, New York, NY.

PMID: 38240490
DOI: 10.1097/CCM.0000000000006171

Executive Summary: Guidelines on Use of Corticosteroids in Critically Ill Patients With Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia Focused Update 2024

Dipayan Chaudhuri et al. Crit Care Med. 2024.

. 2024 May 1;52(5):833-836.

doi: 10.1097/CCM.0000000000006171. Epub 2024 Jan 19.

Authors

Affiliations

¹ Department of Medicine, McMaster University, Hamilton, ON, Canada.
² Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
³ Department of Pharmacy, Mayo Clinic Hospital-Rochester, Rochester, MN.
⁴ Department of Internal Medicine, Rush University Medical Center, Chicago, IL.
⁵ Department of Anesthesiology, CHU Nantes, Université de Nantes, Pôle Anesthésie-Réanimation, Service d'Anesthésie Réanimation Chirurgicale, Hôtel Dieu, Nantes, France.
⁶ Department of Internal Medicine, Wake Forest School of Medicine, Atrium Health, Carolinas Medical Center, Charlotte, NC.
⁷ Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, PA.
⁸ Department of Endocrinology, Diabetes and Metabolism, Endocrine and Metabolism Institute, Cleveland Clinic, Cleveland, OH.
⁹ McMaster University, Hamilton, ON, Canada.
¹⁰ Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University, Atlanta, GA.
¹¹ Division of Pulmonary, Critical Care, and Sleep Medicine, University of Miami Miller School of Medicine, Miami, FL.
¹² Division of Critical Care Medicine, Albert Einstein College of Medicine, Bronx, NY.
¹³ Malcolm Fisher Department of Intensive Care Medicine, Critical Care Program, The George Institute for Global Health, UNSW Sydney, Newtown, NSW, Australia.
¹⁴ Malcolm Fisher Department of Intensive Care, Royal North Shore Hospital, St Leonards, NSW, Australia.
¹⁵ Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI.
¹⁶ Division of Pulmonary and Critical Care Medicine, Henry Ford Hospital, Detroit, MI.
¹⁷ Division of Pediatric Critical Care, Department of Pediatrics, University of Ottawa, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
¹⁸ King Hussein Cancer Center Department of Pharmacy, Amman, Jordan.
¹⁹ Department of Emergency Medicine and Critical Care Medicine, University of Pennsylvania Health System, Philadelphia, PA.
²⁰ Division of Critical Care, Department of Medicine, Centre for Heart Lung Innovation St. Paul's Hospital University of British Columbia, Vancouver, BC, Canada.
²¹ Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, TX.
²² Department of Neurology [Neurocritical Care], Atrium Wake Forest School of Medicine, Winston Salem, NC.
²³ Department of Internal Medicine, Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI.
²⁴ Intensive Care Unit, Service de Réanimation Polyvalente, Hôpital de Gonesse, Grenoble, France.
²⁵ Department of Intensive Care, Raymond Poincaré Hospital, Assistance Publique-Hôpitaux de Paris, Garches, France.
²⁶ School of Medicine Simone Veil, University of Versailles Saint Quentin, University Paris-Saclay, Versaillles, France.
²⁷ IHU Prometheus Fédération Hospitalo-Universitaire SEPSIS, University Paris-Saclay, INSERM, Garches, France.
²⁸ Department of Anesthesiology and Critical Care Medicine, Critical Care Center, Memorial Sloan Kettering Cancer Center, New York, NY.

PMID: 38240490
DOI: 10.1097/CCM.0000000000006171

No abstract available

PubMed Disclaimer

Conflict of interest statement

Dr. Balk received funding from Dompe Pharmaceuticals, Merck, and BioMerieux. Dr. Sarwal’s institution receives funding from Biogen, Bard, Novartis, CVR Global, Lung Pacer, the National Institute on Aging (R01 AG066910-01), Shaltout, and Butterfly. Dr. Gershengorn disclosed that she served as an advisory board member for Gilead Sciences. Dr. Menon received funding from the Canadian Institutes of Health Research. Dr. Jayaprakash disclosed that she was the site principle investigator for sponsored trials through Abott Laboratories and BioCogniV. Dr. Russell reports patents owned by the University of British Columbia (UBC) that are related to the use of PCSK9 inhibitor(s) in sepsis and related to the use of vasopressin in septic shock and a patent owned by Ferring for use of selepressin in septic shock. Dr. Russell is an inventor on these patents. Dr. Russell was a founder, Director and shareholder in Cyon Therapeutics and is a shareholder in Molecular You Corp. Dr. Russell is no longer actively consulting for any industry. Dr. Russell reports receiving consulting fees in the last 3 years from: 1) SIB Therapeutics LLC (developing a sepsis drug). 2) Ferring Pharmaceuticals (manufactures vasopressin and developing selepressin). 3) Dr. Russell was a funded member of the Data and Safety Monitoring Board of an NIH-sponsored trial of plasma in COVID-19 (PASS-IT-ON) (2020–2021). 4) PAR Pharma (sells prepared bags of vasopressin). Dr. Russell reports having received an investigator-initiated grant from Grifols (entitled “Is HBP a mechanism of albumin’s efficacy in human septic shock?”) that was provided to and administered by UBC. Dr. Russell was a nonfunded Science Advisor and member, Government of Canada COVID-19 Therapeutics Task Force (June 2020 to 2021). Dr. Asehnoune received funding from LFB and Edwards Lifecience Baxter. Dr. Spencer-Segal received funding from Camurus AB, Chiasma, and Recordati Rare Diseases. Dr. Esper received funding from Honeywell. The remaining authors have disclosed that they do not have any potential conflicts of interest.

References

1. Annane D, Pastores SM, Arlt W, et al.: Critical illness-related corticosteroid insufficiency (CIRCI): A narrative review from a Multispecialty Task Force of the Society of Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM). Intensive Care Med. 2017; 43:1781–1792
1. Marik PE, Pastores SM, Annane D, et al.; American College of Critical Care Medicine: Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med. 2008; 36:1937–1949
1. Annane D, Pastores SM, Rochwerg B, et al.: Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I). Crit Care Med. 2017; 45:2078–2088
1. Pastores SM, Annane D, Rochwerg B; Corticosteroid Guideline Task Force of SCCM and ESICM: Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part II): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017. Crit Care Med. 2018; 46:146–148
1. Annane D, Renault A, Brun-Buisson C, et al.; CRICS-TRIGGERSEP Network: Hydrocortisone plus fludrocortisone for adults with septic shock. N Engl J Med. 2018; 378:809–818

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Executive Summary: Guidelines on Use of Corticosteroids in Critically Ill Patients With Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia Focused Update 2024

Affiliations

Executive Summary: Guidelines on Use of Corticosteroids in Critically Ill Patients With Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia Focused Update 2024

Authors

Affiliations

Conflict of interest statement

References

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LinkOut - more resources

Full Text Sources

Medical