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Comment
. 2024 Jan 18;187(2):271-273.
doi: 10.1016/j.cell.2023.12.021.

A holistic view of the malignant organism we call glioblastoma

Salma Baig  1 , Frank Winkler  2
Affiliations
Free article
Comment

A holistic view of the malignant organism we call glioblastoma

Salma Baig et al. Cell. .
Free article

Abstract

Tumors are not simply a chaotic mass of mutated cells but can follow complex organizational principles, including in space. In this issue of Cell, Mathur and colleagues reconstruct a 3D genomic, epigenomic, and transcriptomic spatial cartograph of glioblastoma, offering a "whole-tumor" perspective with patterns of clonal expansion that are embedded in neurodevelopmental hierarchy.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective.
    Mathur R, Wang Q, Schupp PG, Nikolic A, Hilz S, Hong C, Grishanina NR, Kwok D, Stevers NO, Jin Q, Youngblood MW, Stasiak LA, Hou Y, Wang J, Yamaguchi TN, Lafontaine M, Shai A, Smirnov IV, Solomon DA, Chang SM, Hervey-Jumper SL, Berger MS, Lupo JM, Okada H, Phillips JJ, Boutros PC, Gallo M, Oldham MC, Yue F, Costello JF. Mathur R, et al. Cell. 2024 Jan 18;187(2):446-463.e16. doi: 10.1016/j.cell.2023.12.013. Cell. 2024. PMID: 38242087 Free PMC article.

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