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Comment
. 2024 Jan 18;187(2):273-275.
doi: 10.1016/j.cell.2023.12.023.

Making glaucoma genetic studies more diverse

David A Mackey  1 , Sandra E Staffieri  2
Affiliations
Free article
Comment

Making glaucoma genetic studies more diverse

David A Mackey et al. Cell. .
Free article

Abstract

Although the blinding eye disease glaucoma is more common in people of African ancestry, previous genetic studies predominantly involved European subjects. In this issue of Cell, O'Brien et al. report a genome-wide association study for glaucoma in individuals of African ancestry, showing overlap with European studies and refining an African polygenic risk score.

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Conflict of interest statement

Declaration of interests D.A.M. has received consulting fees from Novartis and from Editas. The Center for Eye Research Australia (S.E.S.) receives Operational Infrastructure Support from the Victorian Government.

Comment on

  • A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.
    Verma SS, Gudiseva HV, Chavali VRM, Salowe RJ, Bradford Y, Guare L, Lucas A, Collins DW, Vrathasha V, Nair RM, Rathi S, Zhao B, He J, Lee R, Zenebe-Gete S, Bowman AS, McHugh CP, Zody MC, Pistilli M, Khachatryan N, Daniel E, Murphy W, Henderer J; Regeneron Genetics Center; Kinzy TG, Iyengar SK, Peachey NS; VA Million Veteran Program; Taylor KD, Guo X, Chen YI, Zangwill L, Girkin C, Ayyagari R, Liebmann J, Chuka-Okosa CM, Williams SE, Akafo S, Budenz DL, Olawoye OO, Ramsay M, Ashaye A, Akpa OM, Aung T, Wiggs JL, Ross AG, Cui QN, Addis V, Lehman A, Miller-Ellis E, Sankar PS, Williams SM, Ying GS, Cooke Bailey J, Rotter JI, Weinreb R, Khor CC, Hauser MA, Ritchie MD, O'Brien JM. Verma SS, et al. Cell. 2024 Jan 18;187(2):464-480.e10. doi: 10.1016/j.cell.2023.12.006. Cell. 2024. PMID: 38242088 Free PMC article.

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