Current clinical applications of Cerenkov luminescence for intraoperative molecular imaging
- PMID: 38243119
- PMCID: PMC11784920
- DOI: 10.1007/s00259-024-06602-3
Current clinical applications of Cerenkov luminescence for intraoperative molecular imaging
Erratum in
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Correction to: Current clinical applications of Cerenkov luminescence for intraoperative molecular imaging.Eur J Nucl Med Mol Imaging. 2024 Oct;51(12):3809. doi: 10.1007/s00259-024-06832-5. Eur J Nucl Med Mol Imaging. 2024. PMID: 38990310 No abstract available.
Abstract
Background: Cerenkov luminescence imaging (CLI) is a new emerging technology that can be used for optical imaging of approved radiotracers, both in a preclinical, and even more recently, in a clinical context with rapid imaging times, low costs, and detection in real-time (Grootendorst et al. Clin Transl Imaging 4(5):353-66, 2016); Wang et al. Photonics 9(6):390, 2022). This brief review provides an overview of clinical applications of CLI with a focus on intraoperative margin assessment (IMA) to address shortcomings and provide insight for future work in this application.
Methods: A literature review was performed using PubMed using the search words Cerenkov luminescence imaging (CLI), intraoperative margin assessment (IMA), and image-guided surgery. Articles were selected based on title, abstract, content, and application.
Results: Original research was summarized to examine advantages and limitations of CLI compared to other modalities for IMA. The characteristics of Cerenkov luminescence (CL) are defined, and results from relevant clinical trials are discussed. Prospects of ongoing clinical trials are reviewed, along with technological advancements related to CLI.
Conclusion: CLI is a proven method for molecular imaging and shows feasibility for determining intraoperative margins if future work involves establishing quantitative approaches for attenuation and scattering, depth analysis, and radiation safety for CLI at a larger scale.
Keywords: Cerenkov luminescence imaging; Image-guided surgery; Intraoperative margin assessment; Molecular imaging.
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Conflict of interest statement
Competing Interests
The authors have no relevant financial or non-financial interests to disclose.
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