The effect of prostacyclin (PGT2) on platelet behaviour. Thrombus formation in vivo and bleeding time
- PMID: 382434
The effect of prostacyclin (PGT2) on platelet behaviour. Thrombus formation in vivo and bleeding time
Abstract
Prostacyclin (PGI2) infused intravenously into anaesthetized rabbits inhibited electrically-induced thrombus formation in the carotid artery, increased bleeding time and inhibited ex vivo platelet aggregation induced by ADP or arachidonic acid. The increase in bleeding time and the inhibition of ex vivo platelet aggregation lasted for as long as the infusion of PGI2 was maintained but rapidly disappeared after infusion was stopped. Prostacyclin is a more potent inhibitor of platelet function, in vivo than prostaglandin E1 (PGE1) or prostaglandin D2 (PGD2). The effects of prostacyclin on all parameters studied except blood pressure were potentiated by the concomitant administration of theophylline, a phosphodiesterase inhibitor.
Similar articles
-
Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species.Prostaglandins. 1978 Sep;16(3):373-88. doi: 10.1016/0090-6980(78)90216-2. Prostaglandins. 1978. PMID: 364545
-
Anti-aggregatory effect of prostacyclin (PGI2) in vivo.Br J Pharmacol. 1979 May;66(1):10-2. doi: 10.1111/j.1476-5381.1979.tb16090.x. Br J Pharmacol. 1979. PMID: 378308 Free PMC article.
-
Prostaglandins E1 and E2, but neither prostacyclin nor prostaglandin D2 have anti-aggregating activity in chicken blood.Arch Int Pharmacodyn Ther. 1981 Feb;249(2):306-8. Arch Int Pharmacodyn Ther. 1981. PMID: 7013724 No abstract available.
-
Thromboxane A2, prostacyclin and aspirin: effects on vascular tone and platelet aggregation.Circulation. 1980 Dec;62(6 Pt 2):V19-25. Circulation. 1980. PMID: 7002350 Review.
-
The role of prostacyclin in vascular tissue.Fed Proc. 1979 Jan;38(1):66-71. Fed Proc. 1979. PMID: 215463 Review.
Cited by
-
Inhibition of human platelet activation by polymorphonuclear leukocytes.Br J Pharmacol. 1990 Oct;101(2):253-6. doi: 10.1111/j.1476-5381.1990.tb12696.x. Br J Pharmacol. 1990. PMID: 2257433 Free PMC article.
-
Inhibition and subsequent enhancement of platelet responsiveness by prostacyclin in the rabbit. Relationship to platelet adenosine 3',5'-cyclic monophosphate.J Clin Invest. 1985 Jul;76(1):233-40. doi: 10.1172/JCI111952. J Clin Invest. 1985. PMID: 2991338 Free PMC article.
-
Beraprost: a review of its pharmacology and therapeutic efficacy in the treatment of peripheral arterial disease and pulmonary arterial hypertension.Drugs. 2002;62(1):107-33. doi: 10.2165/00003495-200262010-00005. Drugs. 2002. PMID: 11790158 Review.
-
Is there a place for prostacyclin in the treatment of septic shock?Intensive Care Med. 2001 Jul;27(7):1110-2. doi: 10.1007/s001340100988. Intensive Care Med. 2001. PMID: 11534556 No abstract available.
-
Prostacyclin.J R Soc Med. 1983 Apr;76(4):245-9. doi: 10.1177/014107688307600401. J R Soc Med. 1983. PMID: 6341583 Free PMC article. No abstract available.